INT231266

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 3.95
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocytes 1
brain 1
dorsal root ganglia 1
kidney 1
Prh1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 18 99.96 Very High Very High Very High
Action potential 9 99.08 Very High Very High Very High
TRP channel 1 97.50 Very High Very High Very High
Hippocampus 2 85.68 High High
cytokine 29 85.24 High High
imagery 28 84.64 Quite High
Serotonin 4 77.84 Quite High
ischemia 4 76.28 Quite High
cINOD 8 64.32 Quite High
sodium channel 11 64.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 29 97.42 Very High Very High Very High
Polycystic Kidney Disease 2 96.00 Very High Very High Very High
Viral Infection 7 92.84 High High
Schizophrenia 10 92.68 High High
Disease 129 91.84 High High
Cataract 1 89.84 High High
Glaucoma 1 89.44 High High
Muscular Dystrophy 4 87.12 High High
Cardiomyopathy 4 85.36 High High
Premature Aging 4 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, it implies the possibility that A-type lamin expression in non-hematopoietic cells influences the function and development of these lymphocytes.


Gene_expression (expression) of A-type in lymphocytes
1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0 Pain Relevance 0.07
This implies that A-type lamin function/expression is not required in these cell types for normal development and homeostasis.
Gene_expression (expression) of A-type
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0 Pain Relevance 0.08
One gene, LMNA, encodes the A-type nuclear lamins, which produce the predominant A-type lamin proteins A and C.
Gene_expression (produce) of A-type
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.52 Pain Relevance 0
One gene, LMNA, encodes the A-type nuclear lamins, which produce the predominant A-type lamin proteins A and C.
Gene_expression (produce) of A-type
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.53 Pain Relevance 0
Specifically, Kcnip4 modulates A-type potassium channels and has been shown to increase expression of cardiac A-type Kv-4 channels [31].
Gene_expression (expression) of A-type associated with potassium channel
5) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.53 Pain Relevance 0.29
Specifically, Kcnip4 modulates A-type potassium channels and has been shown to increase expression of cardiac A-type Kv-4 channels [31].
Gene_expression (modulates) of A-type associated with potassium channel
6) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 0.60 Pain Relevance 0.28
In addition to examining this RNA sample for the presence of Hoxc11-specific transcripts, we determined whether there was evidence for expression of the remaining AbdB-type Hoxc genes (Hoxc9, Hoxc10, Hoxc12, and Hoxc13), as well as for the Hoxc11 and Hoxc10 paralogous genes (Hoxa11, Hoxd11, and Hoxa10, Hoxd10).
Gene_expression (expression) of AbdB-type
7) Confidence 0.05 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570687 Disease Relevance 0.06 Pain Relevance 0
Polycystic kidney disease 2-like 1 (PKD2L1) and polycystic kidney disease 1-like 3 (PKD1L3), two members of the transient receptor potential channel family, have been identified in a subset of TCs distinct from sweet, umami or bitter cells [2] and PKD2L1-positive cells co-express various Type III cell marker proteins [9]–[12].
Gene_expression (express) of Type in kidney associated with trp channel and polycystic kidney disease
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939079 Disease Relevance 0.24 Pain Relevance 0.15
B type lamins are essential, while the A-type lamins are believed to be non-essential and are only expressed in differentiated cells (Foisner, 2001).
Gene_expression (expressed) of A-type
9) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.41 Pain Relevance 0
It is worth noting that these risk alleles at the NRG1 locus also have been associated with increased expression of Type I and IV Nrg1 (Law et al., 2006).
Gene_expression (expression) of Type
10) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.32 Pain Relevance 0.04
Subsets of primary sensory neurons within the dorsal root ganglia (DRG) express Type III Nrg1 and ?
Gene_expression (express) of Type in dorsal root ganglia
11) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
Various transgenic mice have been generated, such as mice over expressing Rab9, a protein involved in intracellular trafficking [131-133], or mice expressing NPC1 only in one particular brain cell type [134].
Gene_expression (expressing) of type in brain associated with targeted disruption
12) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.33 Pain Relevance 0.11
Cell type-specific overexpression can also be achieved by infecting a Cre-expressing mouse line with a virus where a flox-stop cassette precedes the gene of interest.
Gene_expression (overexpression) of type
13) Confidence 0.01 Published 2008 Journal Developmental Dynamics Section Body Doc Link PMC2532702 Disease Relevance 0.42 Pain Relevance 0

General Comments

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