INT231295

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 0.70
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
neurons 4
lamina 1
Grin2d (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 491 100.00 Very High Very High Very High
Inflammation 6 99.84 Very High Very High Very High
cINOD 1 98.42 Very High Very High Very High
Dorsal horn 56 98.04 Very High Very High Very High
Spinal cord 52 96.16 Very High Very High Very High
Dorsal horn neuron 42 92.40 High High
Hippocampus 84 89.68 High High
Nicotine 1 86.84 High High
Neuronal excitability 15 86.08 High High
Glutamate 74 82.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.84 Very High Very High Very High
Aging 114 93.60 High High
Cognitive Disorder 25 86.08 High High
Viral Meningitis 3 85.44 High High
Targeted Disruption 47 77.08 Quite High
Disease 17 28.92 Quite Low
Stress 5 17.00 Low Low
Death 44 5.00 Very Low Very Low Very Low
Neuropathic Pain 34 5.00 Very Low Very Low Very Low
Pain 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests the possibility of a functional upregulation of NR2D-containing receptors in PrP-null mouse neurons.
Positive_regulation (upregulation) of NR2D-containing in neurons
1) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
Collectively, these data indicate that hippocampal neurons in both WT and PrP-null mice express similar levels of NR2D surface protein, with no apparent differences in subcellular distributions of NR2D subunits.
Positive_regulation (levels) of NR2D in neurons
2) Confidence 0.41 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.15 Pain Relevance 0
We show that PrP-null mouse neurons exhibit enhanced and drastically prolonged N-methyl-d-aspartate (NMDA)–evoked currents as a result of a functional upregulation of NMDA receptors (NMDARs) containing NR2D subunits.
Positive_regulation (upregulation) of NR2D in neurons associated with nmda receptor
3) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364707 Disease Relevance 0.09 Pain Relevance 0.17
Consistent with these findings, Momiyama [12] reports the existence of NR2D-like single channel conductance at extrasynaptic regions in lamina II of the adult rats.


Positive_regulation (conductance) of NR2D-like in lamina
4) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.13
Pharmacological test of NR2 subunit confirms the expression of NR2A/B and NR2C/D type NMDA receptors
Positive_regulation (receptors) of NR2C/D associated with nmda receptor
5) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.37
Further support for the presence of NR2D is that NMDA receptors with NR2D-like single channel conductance have been reported for lamina II neurons in rat dorsal horn [39,40].
Positive_regulation (conductance) of NR2D-like in neurons associated with nmda receptor and dorsal horn
6) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.51
When NMDA was co-applied with EAB318, the current voltage relationship shifted to a larger g(-90 mV)/g(MIC) ratio and a more negative VMIC, suggesting that a higher proportion of NR2C/D type NMDA receptors were revealed (Figure 2C).
Positive_regulation (proportion) of NR2C/D associated with nmda receptor
7) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.41
Pharmacological test of NR2 subunit confirms the expression of NR2A/B and NR2C/D type NMDA receptors
Positive_regulation (receptors) of NR2C/D associated with nmda receptor
8) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.33
Likewise, sulindac, a non-steriodal anti-inflammatory drug (NSAID), attenuated age-related deficits in memory by decreasing inflammation, while increasing expression levels of the NMDA receptor subunits, GluN1 and GluN2B (Mesches et al., 2004).
Positive_regulation (increasing) of GluN2B associated with inflammation, nmda receptor and cinod
9) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.47 Pain Relevance 0.57

General Comments

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