INT231296

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.65
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neurons 2
neurite 2
hippocampus 1
Syn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 48 99.38 Very High Very High Very High
Nerve growth factor 68 96.36 Very High Very High Very High
Pyramidal cell 9 55.24 Quite High
long-term potentiation 29 50.00 Quite Low
GABAergic 44 31.92 Quite Low
depression 34 26.80 Quite Low
ketamine 3 16.08 Low Low
cerebral cortex 28 5.00 Very Low Very Low Very Low
Neurotransmitter 25 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 50 98.36 Very High Very High Very High
Targeted Disruption 21 83.88 Quite High
Depression 34 26.80 Quite Low
Cognitive Disorder 54 5.00 Very Low Very Low Very Low
Apoptosis 25 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 18 5.00 Very Low Very Low Very Low
Death 17 5.00 Very Low Very Low Very Low
Anxiety Disorder 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fig S5 shows synapsin I (presynaptic protein) and NR1 (postsynaptic protein) expression patterns as visualized in WT and PrP-null mature primary hippocampal cultured neurons.
Gene_expression (expression) of synapsin I in neurons
1) Confidence 0.23 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
Target sequences for knockdown of Syn-1 were: shSyn-1#1 (GGATTAGGAGAGCAGAGAT), shSyn-1#2 (GTGAGATCAACGGACAGAA).
Gene_expression (were) of shSyn-1
2) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.09 Pain Relevance 0.13
Target sequences for knockdown of Syn-1 were: shSyn-1#1 (GGATTAGGAGAGCAGAGAT), shSyn-1#2 (GTGAGATCAACGGACAGAA).
Gene_expression (were) of shSyn-1
3) Confidence 0.10 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.09 Pain Relevance 0.13
Cells transfected with shSyn-1 had 1.74 ± 0.15 whereas control cells had 2.80 ± 0.20 neurites per cell on the 5th day of NGF treatment.
Gene_expression (transfected) of shSyn-1 in neurites associated with nerve growth factor
4) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.07 Pain Relevance 0.05
We thus analyzed several aspects of neurite outgrowth in PC12 (DN-Akt) cells transfected with shSyn-1#2.
Gene_expression (transfected) of shSyn-1 in neurite
5) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.08 Pain Relevance 0.03
Furthermore electrophysiological recordings revealed the emergence of CNQX-sensitive spontaneous synaptic currents in these neurons in accordance with vGluT1 and synapsin expression (8 out of 30 cells recorded at 22.5±0.9 DPI; Figure 15E–15F”).
Gene_expression (expression) of synapsin in neurons associated with infection
6) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.31 Pain Relevance 0
Also, quantitative RT PCR and protein expression, determined by Western blotting, failed to uncover differences in synapsin1 or synaptophysin gene expression at any of the time points tested (days 8, 14, and 30).
Gene_expression (expression) of synapsin1
7) Confidence 0.01 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0 Pain Relevance 0.03
Quantitative RT PCR and/or Western blotting using extracts of whole hippocampus did not reveal differences in expression of synaptic proteins (synapsin1, synaptophysin), postsynaptic receptor proteins (GABAA1,2,3,4; NMDAR1, R2A, R2B) or BDNF, as potential mediating neurotrophic factor [20,32] (data not shown).


Gene_expression (expression) of synapsin1 in hippocampus associated with hippocampus
8) Confidence 0.01 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0 Pain Relevance 0.11

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