INT231297

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 1.25
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
neurons 2
lamina 2
frontal cortex 2
synapse 1
Grin2d (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 59 99.68 Very High Very High Very High
nMDA receptor 631 99.52 Very High Very High Very High
depression 21 96.64 Very High Very High Very High
Hippocampus 148 95.12 Very High Very High Very High
Neurotransmitter 3 93.20 High High
Glutamate 93 90.88 High High
Dorsal horn neuron 33 88.20 High High
antagonist 134 84.64 Quite High
projection neuron 26 80.48 Quite High
Spinal cord 48 78.24 Quite High
Disease Link Frequency Relevance Heat
Aging 228 99.92 Very High Very High Very High
Urological Neuroanatomy 30 99.32 Very High Very High Very High
Depression 21 96.64 Very High Very High Very High
Death 34 88.20 High High
Injury 7 72.48 Quite High
Myelodysplastic Syndromes 7 57.08 Quite High
Sprains And Strains 18 35.64 Quite Low
Adhesions 6 25.12 Quite Low
Targeted Disruption 45 17.88 Low Low
Drug Induced Neurotoxicity 11 9.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For NR2D and PrP colocalization, NR2D (1:200; Santa Cruz Biotechnology, Inc.) and mouse monoclonal anti-PrP (1:200; Chemicon) antibodies were used and conjugated to AlexaFluor488 IgG and AlexaFluor546 IgG, respectively.
Localization (colocalization) of NR2D
1) Confidence 0.71 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.06 Pain Relevance 0.06
For NR2D and PrP colocalization, NR2D (1:200; Santa Cruz Biotechnology, Inc.) and mouse monoclonal anti-PrP (1:200; Chemicon) antibodies were used and conjugated to AlexaFluor488 IgG and AlexaFluor546 IgG, respectively.
Localization (colocalization) of NR2D
2) Confidence 0.54 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.06 Pain Relevance 0.06
Momiyama (2000) has suggested an extrasynaptic localization of NR2D containing NMDA receptors by lamina II neurons in the dorsal horn.
Localization (localization) of NR2D in neurons associated with nmda receptor and dorsal horn
3) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0.07 Pain Relevance 0.54
While the dominant synaptic receptors are NR2A/B type receptors, our bath application data indicate that NR2C/D receptors as well as NR2A/B receptors are expressed by inhibitory neurons and these may be extrasynaptic.
Localization (receptors) of NR2C/D in neurons
4) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.15
These results support our interpretation that both types of NR2 subunits, NR2A/B and NR2C/D are present on inhibitory interneurons of lamina II.
Localization (types) of NR2C/D in lamina
5) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.24
This suggests that in the presence of UBP141, most of the NR2C and NR2D containing NMDA receptors are blocked and that NR2A/B type NMDA receptors dominate the current.
Localization (most) of NR2D associated with nmda receptor
6) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.35
While published evidence suggests expression of both NR2A/B and NR2C/D subunit types in the dorsal horn generally, our data, collected on subpopulations of lamina I neurons, show cell specific differences.
Localization (types) of NR2C/D in lamina associated with dorsal horn
7) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.36
The interactions with Mint1 and Veli further link CASK to KIF17b and N-methyl-d-aspartate receptor 2b (Jo et al., 1999; Setou et al., 2000) and regulate vesicle transport of N-methyl-d-aspartate receptor to the synapse (Setou et al., 2000; Wong et al., 2002).
Localization (transport) of N-methyl-d-aspartate receptor in synapse
8) Confidence 0.09 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2447900 Disease Relevance 0 Pain Relevance 0.05
This suggests that, in addition to the declines already discussed in mRNA expression of the GluN2B subunit, there may be an additional effect of aging on GluN2B subunit localization within the synaptic membranes of the frontal cortex.
Localization (localization) of GluN2B in frontal cortex associated with aging and urological neuroanatomy
9) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.61 Pain Relevance 0.27
If some of the decline in synaptic membrane expression were due to a shift to more extra-synaptic localization of GluN2B subunits in the frontal cortex of aged animals, there could also be an increase in LTD (Massey et al., 2004) and/or activation of a CREB shut-off pathway that interferes with induction of brain-derived neurotrophic factor (BDNF) and leads to a loss of mitochondrial membrane potential and cell death (Hardingham et al., 2002).
Localization (localization) of GluN2B in frontal cortex associated with depression, urological neuroanatomy and death
10) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874396 Disease Relevance 0.45 Pain Relevance 0.28

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