INT231302

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2d, Prnp) transport (Grin2d) Golgi apparatus (Prnp)
endoplasmic reticulum (Prnp) nucleolus (Prnp) nucleus (Prnp)
Grin2d (Mus musculus)
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 27 54.88 Quite High
antagonist 9 39.84 Quite Low
tetrodotoxin 18 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
Neuronal excitability 15 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
GABAergic 12 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
hyperexcitability 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 60.80 Quite High
Death 39 52.16 Quite High
Toxicity 12 33.04 Quite Low
Prion Diseases 18 5.00 Very Low Very Low Very Low
Convulsion 12 5.00 Very Low Very Low Very Low
Stroke 12 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 9 5.00 Very Low Very Low Very Low
Scrapie 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PrPC and NR2D subunits could be coimmunoprecipitated from hippocampal homogenate, indicating that NR2D-containing receptors form a protein complex with PrPC, but it is unclear exactly how PrPC functionally inhibits NMDAR activity.
NR2D-containing Binding (complex) of PrPC
1) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.03
PrPC and NR2D subunits could be coimmunoprecipitated from hippocampal homogenate, indicating that NR2D-containing receptors form a protein complex with PrPC, but it is unclear exactly how PrPC functionally inhibits NMDAR activity.
NR2D Binding (complex) of PrPC
2) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.03
To examine whether there is a close association of NR2D subunits and PrPC, we performed coimmunoprecipitations from WT mouse hippocampal homogenate.
NR2D Binding (association) of PrPC
3) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.11 Pain Relevance 0

General Comments

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