INT231303

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.23
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prnp, Helt) cell differentiation (Helt) Golgi apparatus (Prnp)
endoplasmic reticulum (Prnp) nucleolus (Prnp) plasma membrane (Prnp)
Anatomy Link Frequency
neurons 3
glial cells 2
Prnp (Mus musculus)
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 45 97.48 Very High Very High Very High
antagonist 15 53.88 Quite High
Neuronal excitability 25 24.32 Low Low
tetrodotoxin 30 5.00 Very Low Very Low Very Low
imagery 30 5.00 Very Low Very Low Very Low
Hippocampus 25 5.00 Very Low Very Low Very Low
GABAergic 20 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
hyperexcitability 10 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 20 97.16 Very High Very High Very High
Disease Progression 10 84.12 Quite High
Death 65 78.80 Quite High
Prion Diseases 30 76.48 Quite High
Targeted Disruption 50 74.48 Quite High
Scrapie 15 71.36 Quite High
Infection 5 66.48 Quite High
Stroke 20 42.80 Quite Low
Convulsion 20 25.72 Quite Low
Sprains And Strains 10 13.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the presence of PrPC in these neurons appears to impair NR2D receptor function rather than primarily regulating receptor trafficking.
PrPC Binding (presence) of neurons in neurons
1) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.03
However, it is likely that the accumulation of PrPSc aggregates on neurons and glial cells (Rezaie and Lantos, 2001) results in enhanced glutamate levels in the diseased brain as caused by cell damage.
PrPSc Binding (aggregates) of neurons in neurons associated with glutamate
2) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.81 Pain Relevance 0.10
However, it is likely that the accumulation of PrPSc aggregates on neurons and glial cells (Rezaie and Lantos, 2001) results in enhanced glutamate levels in the diseased brain as caused by cell damage.
PrPSc Binding (aggregates) of neurons in neurons associated with glutamate
3) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.81 Pain Relevance 0.10
However, it is likely that the accumulation of PrPSc aggregates on neurons and glial cells (Rezaie and Lantos, 2001) results in enhanced glutamate levels in the diseased brain as caused by cell damage.
PrPSc Binding (aggregates) of neurons in glial cells associated with glutamate
4) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.81 Pain Relevance 0.10
However, it is likely that the accumulation of PrPSc aggregates on neurons and glial cells (Rezaie and Lantos, 2001) results in enhanced glutamate levels in the diseased brain as caused by cell damage.
PrPSc Binding (aggregates) of neurons in glial cells associated with glutamate
5) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.81 Pain Relevance 0.10

General Comments

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