INT231305

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.63
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Prnp, Helt) cell differentiation (Helt) Golgi apparatus (Prnp)
endoplasmic reticulum (Prnp) nucleolus (Prnp) plasma membrane (Prnp)
Anatomy Link Frequency
neurons 3
glial cells 1
Prnp (Mus musculus)
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 18 97.48 Very High Very High Very High
Neuronal excitability 10 24.32 Low Low
tetrodotoxin 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
GABAergic 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
hyperexcitability 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 8 97.80 Very High Very High Very High
Disease Progression 4 84.76 Quite High
Death 26 78.80 Quite High
Prion Diseases 12 76.48 Quite High
Targeted Disruption 20 75.12 Quite High
Scrapie 6 71.36 Quite High
Infection 2 66.48 Quite High
Stroke 8 43.44 Quite Low
Convulsion 8 26.36 Quite Low
Sprains And Strains 4 13.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is likely that the accumulation of PrPSc aggregates on neurons and glial cells (Rezaie and Lantos, 2001) results in enhanced glutamate levels in the diseased brain as caused by cell damage.
Positive_regulation (accumulation) of PrPSc Binding (aggregates) of neurons in neurons associated with glutamate
1) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.81 Pain Relevance 0.10
However, it is likely that the accumulation of PrPSc aggregates on neurons and glial cells (Rezaie and Lantos, 2001) results in enhanced glutamate levels in the diseased brain as caused by cell damage.
Positive_regulation (accumulation) of PrPSc in glial cells Binding (aggregates) of neurons in neurons associated with glutamate
2) Confidence 0.01 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.81 Pain Relevance 0.10

General Comments

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