INT231306

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prnp, Grin1) cytoplasm (Prnp, Grin1) transport (Grin1)
Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
Anatomy Link Frequency
neuronal 1
Prnp (Mus musculus)
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 15 96.32 Very High Very High Very High
tetrodotoxin 18 93.00 High High
Glutamate 27 85.20 High High
hyperexcitability 6 49.08 Quite Low
imagery 18 5.00 Very Low Very Low Very Low
Hippocampus 15 5.00 Very Low Very Low Very Low
GABAergic 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 12 78.96 Quite High
Convulsion 12 73.16 Quite High
Death 39 70.16 Quite High
Stroke 12 15.76 Low Low
Stress 3 11.80 Low Low
Apoptosis 3 10.84 Low Low
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Prion Diseases 18 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 9 5.00 Very Low Very Low Very Low
Scrapie 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future experimentation will be required to dissect the mechanisms by which PrP regulates NMDAR activity.
PrP Regulation (regulates) of NMDAR
1) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.20 Pain Relevance 0.08
To directly measure the effect of PrPC on synaptic NMDAR currents, we recorded miniature excitatory postsynaptic currents (mEPSCs) in mature (12–16 d in vitro [DIV]) primary hippocampal cultures bathed in ZM-aCSF supplemented with tetrodotoxin (TTX), picrotoxin, CNQX, and glycine.
PrPC Regulation (effect) of NMDAR associated with tetrodotoxin
2) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.07 Pain Relevance 0.23
In this context, it is interesting to note that the elevated susceptibility to neuronal damage observed in the PrP-null mice is diminished by the NMDAR blocker MK-801 (Rangel et al., 2007), suggesting the possibility that PrPC may perhaps act by regulating NMDAR function.
PrPC Regulation (regulating) of NMDAR in neuronal
3) Confidence 0.26 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.07 Pain Relevance 0

General Comments

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