INT231312

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prnp, Grin1) cytoplasm (Prnp, Grin1) transport (Grin1)
Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
Anatomy Link Frequency
neurons 1
Prnp (Mus musculus)
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 60.08 Quite High
Glutamate 9 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Neuronal excitability 5 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
GABAergic 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
hyperexcitability 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 53.12 Quite High
Death 13 5.00 Very Low Very Low Very Low
Prion Diseases 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Stroke 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low
Scrapie 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, our data suggest that PrPC is a negative regulator of NMDAR function in hippocampal neurons.


PrPC Negative_regulation (regulator) of NMDAR in neurons
1) Confidence 0.42 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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