INT23132

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1980
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 2.02
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Pnmt) cytoplasm (Pnmt)
Anatomy Link Frequency
nucleus 3
adrenal medulla 2
neurons 1
PEK 1
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Catecholamine 14 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
medulla 17 99.36 Very High Very High Very High
Clonidine 33 99.22 Very High Very High Very High
Morphine 13 98.84 Very High Very High Very High
withdrawal 8 97.16 Very High Very High Very High
agonist 7 94.76 High High
Disease Link Frequency Relevance Heat
Pheochromocytoma 1 99.34 Very High Very High Very High
Glioma 5 97.48 Very High Very High Very High
Hypertrophy 1 95.04 Very High Very High Very High
Urological Neuroanatomy 8 83.24 Quite High
Hypertension 10 76.72 Quite High
Stress 1 62.56 Quite High
Hypotension 6 57.52 Quite High
Heart Rate Under Development 2 25.00 Low Low
Pressure Volume 2 Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In female or hypophysectomized male animals the chronic morphine treatment had no effect on adrenal weight but evoked the increase of PNMT activity.
Positive_regulation (increase) of PNMT associated with morphine
1) Confidence 0.67 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2829923 Disease Relevance 0.10 Pain Relevance 0.69
Clonidine and hydralazine significantly lowered phenylethanolamine N-methyltransferase (PNMT) activity elevated in the nucleus hypothalamicus posterior (NHP) of SHR to the level of KWR, and both drugs or alpha-methyldopa consistently increased PNMT in the nucleus paraventricularis (NPA).
Positive_regulation (increased) of PNMT in nucleus associated with clonidine
2) Confidence 0.67 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.30 Pain Relevance 0.63
Peripherally active hydralazine also increased PNMT activity in the NTS, and antagonized the activity elevated in the A1 cell area of SHR to the level of KWR.
Positive_regulation (increased) of PNMT
3) Confidence 0.67 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.28 Pain Relevance 0.62
Several medullary cardiovascular relay nuclei contain high concentrations of epinephrine and phenylethanolamine-N-methyl transferase (PNMT), the enzyme which catalyzes the conversion of norepinephrine to epinephrine.
Positive_regulation (concentrations) of PNMT
4) Confidence 0.49 Published 1982 Journal Clin Exp Hypertens A Section Abstract Doc Link 7105433 Disease Relevance 0.11 Pain Relevance 0
Chromaffin cells from all three species reacted for TH, DBH and PNMT in co-culture and were histo-fluorescent.
Positive_regulation (reacted) of PNMT in Chromaffin cells
5) Confidence 0.49 Published 1989 Journal Exp Brain Res Section Abstract Doc Link 2568944 Disease Relevance 0.34 Pain Relevance 0.45
Agents used as controls were SKF29661, which is a selective peripheral PNMT inhibitor, SKF64139, a PNMT inhibitor that inhibits equally both alpha-2-adrenoceptor activity and PNMT, and yohimbine, an alpha-2-adrenoceptor inhibitor that does not inhibit PNMT.
Positive_regulation (peripheral) of PNMT
6) Confidence 0.49 Published 1996 Journal Neuropsychobiology Section Abstract Doc Link 8904737 Disease Relevance 0 Pain Relevance 0.07
Clonidine and hydralazine significantly lowered phenylethanolamine N-methyltransferase (PNMT) activity elevated in the nucleus hypothalamicus posterior (NHP) of SHR to the level of KWR, and both drugs or alpha-methyldopa consistently increased PNMT in the nucleus paraventricularis (NPA).
Positive_regulation (elevated) of PNMT in nucleus associated with clonidine
7) Confidence 0.45 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.31 Pain Relevance 0.64
Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h.
Positive_regulation (increased) of PNMT
8) Confidence 0.45 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
In vivo, PNMT and tyrosine hydroxylase (TH) mRNA levels increase in rat adrenal medulla after a single injection of clonidine.
Positive_regulation (increase) of PNMT in adrenal medulla associated with medulla and clonidine
9) Confidence 0.45 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.50
Several medullary cardiovascular relay nuclei contain high concentrations of epinephrine and phenylethanolamine-N-methyl transferase (PNMT), the enzyme which catalyzes the conversion of norepinephrine to epinephrine.
Positive_regulation (concentrations) of phenylethanolamine-N-methyl transferase
10) Confidence 0.43 Published 1982 Journal Clin Exp Hypertens A Section Abstract Doc Link 7105433 Disease Relevance 0.11 Pain Relevance 0
Clonidine and hydralazine significantly lowered phenylethanolamine N-methyltransferase (PNMT) activity elevated in the nucleus hypothalamicus posterior (NHP) of SHR to the level of KWR, and both drugs or alpha-methyldopa consistently increased PNMT in the nucleus paraventricularis (NPA).
Positive_regulation (elevated) of phenylethanolamine N-methyltransferase in nucleus associated with clonidine
11) Confidence 0.43 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.32 Pain Relevance 0.65
These glucocorticoids stimulate phenylethanolamine-N-methyltransferase, which transforms norepinephrine to epinephrine.
Positive_regulation (stimulate) of phenylethanolamine-N-methyltransferase
12) Confidence 0.41 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2385755 Disease Relevance 0 Pain Relevance 0.57
Adrenal phenylethanolamine-N-methyltransferase activity was unchanged during the time course studied.
Neg (unchanged) Positive_regulation (unchanged) of phenylethanolamine-N-methyltransferase
13) Confidence 0.39 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2860239 Disease Relevance 0 Pain Relevance 1.13
Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h.
Positive_regulation (increased) of phenylethanolamine N-methyl-transferase
14) Confidence 0.28 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0
Induction of c-fos immunoreactivity in tyrosine hydroxylase and phenylethanolamine-N-methyltransferase immunoreactive neurons of the medulla oblongata of the rat after phosphate-buffered saline load in the urethane-anaesthetized rat.
Positive_regulation (Induction) of phenylethanolamine-N-methyltransferase in neurons associated with medulla and anesthesia
15) Confidence 0.28 Published 1993 Journal Brain Res. Section Title Doc Link 8095432 Disease Relevance 0 Pain Relevance 0.29
In this report, we examined the interaction between butyrate differentiation of rat pheochromocytoma cells and cholinergic-nicotinic induction of the neuropeptide (enkephalin) and catecholamine-related biosynthetic enzymes (tyrosine hydroxylase, dopamine beta-hydroxylase, phenylethanolamine N-methyltransferase).
Positive_regulation (induction) of phenylethanolamine N-methyltransferase associated with dopamine, catecholamine, neuropeptide, enkephalin and pheochromocytoma
16) Confidence 0.24 Published 2003 Journal Pediatr. Res. Section Abstract Doc Link 12508089 Disease Relevance 0.10 Pain Relevance 0.29
Veratridine treatment also increased the levels of mRNAs for the catecholamine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT), and proenkephalin A (PEK).
Positive_regulation (increased) of catecholamine biosynthetic enzyme phenylethanolamine N-methyltransferase in PEK associated with catecholamine
17) Confidence 0.03 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7912405 Disease Relevance 0.06 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox