INT231349

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Context Info
Confidence 0.23
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10, TNF) extracellular region (Il10, TNF) intracellular (Il10, TNF)
signal transduction (TNF) plasma membrane (TNF) extracellular matrix organization (TNF)
Il10 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 99.78 Very High Very High Very High
Inflammation 27 99.58 Very High Very High Very High
cINOD 1 92.32 High High
dexamethasone 1 88.88 High High
Inflammatory response 2 85.56 High High
vagus nerve 1 73.28 Quite High
Multiple sclerosis 19 60.64 Quite High
ischemia 4 58.36 Quite High
Central nervous system 10 54.20 Quite High
Glutamate 7 47.72 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 99.58 Very High Very High Very High
Disease 51 79.08 Quite High
Necrosis 5 78.20 Quite High
Cancer 4 77.84 Quite High
Neurodegenerative Disease 9 72.56 Quite High
Injury 7 66.52 Quite High
Demyelinating Disease 24 60.64 Quite High
Brain Injury 1 59.64 Quite High
Cv Unclassified Under Development 3 58.36 Quite High
Neurological Disease 2 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with interleukin 10 (IL-10) inhibited TNF production almost completely and cell migration by 60%.
IL-10 Negative_regulation (inhibited) of Gene_expression (production) of TNF
1) Confidence 0.23 Published 1997 Journal Mediators Inflamm Section Abstract Doc Link PMC2365839 Disease Relevance 0.85 Pain Relevance 0.40
Anti-inflammatory cytokines including IL-10, IL-13 and IL-4 can inhibit TNF production [89-92].
IL-10 Negative_regulation (inhibit) of Gene_expression (production) of TNF associated with inflammation and cytokine
2) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.96 Pain Relevance 0.27

General Comments

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