INT231373

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.98
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pmp22) cell cycle (Pmp22)
Anatomy Link Frequency
dorsal root 1
Pmp22 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 56 99.54 Very High Very High Very High
Peripheral nerve injury 8 98.20 Very High Very High Very High
Neuropathic pain 104 97.32 Very High Very High Very High
allodynia 40 96.84 Very High Very High Very High
dorsal root ganglion 14 92.32 High High
antagonist 12 79.32 Quite High
Spinal cord 22 76.56 Quite High
Sciatic nerve 22 70.92 Quite High
Thermal hyperalgesia 6 54.96 Quite High
cytokine 2 42.32 Quite Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 62 99.54 Very High Very High Very High
Nervous System Injury 56 97.76 Very High Very High Very High
Neuropathic Pain 158 97.32 Very High Very High Very High
Injury 30 97.28 Very High Very High Very High
Ganglion Cysts 16 92.32 High High
Hyperalgesia 20 54.96 Quite High
Nociception 56 39.68 Quite Low
Pain 84 35.84 Quite Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, LPA1 receptor-mediated demyelination was evidenced by down-regulation of myelin-associated proteins, such as MBP and peripheral myelin protein 22 kDa (PMP22), in the dorsal root after LPA injection or peripheral nerve injury.
Negative_regulation (regulation) of PMP22 in dorsal root associated with demyelination, nervous system injury and peripheral nerve injury
1) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.72 Pain Relevance 1.09
We obtained evidence that LPA1 receptor activation mediates down-regulation of myelin proteins, such as peripheral myelin protein PMP22, myelin basic protein MBP, and myelin protein zero MP0, in in vivo injury models and ex vivo culture models [73,74].
Negative_regulation (regulation) of PMP22 associated with injury
2) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.27 Pain Relevance 0.66

General Comments

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