INT231377

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.55
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) plasma membrane (Lpar1) cytoplasm (Lpar1)
signal transducer activity (Lpar1)
Anatomy Link Frequency
spinal cord 2
peripheral nerve 2
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 132 99.90 Very High Very High Very High
Neuropathic pain 116 99.80 Very High Very High Very High
Hyperalgesia 18 99.56 Very High Very High Very High
Demyelination 122 97.90 Very High Very High Very High
Peripheral nerve injury 4 97.36 Very High Very High Very High
fibrosis 9 96.28 Very High Very High Very High
intrathecal 25 92.76 High High
allodynia 41 82.60 Quite High
Thermal hyperalgesia 10 81.60 Quite High
dorsal root ganglion 21 79.12 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 166 99.80 Very High Very High Very High
Hyperalgesia 28 99.56 Very High Very High Very High
Demyelinating Disease 135 97.90 Very High Very High Very High
Injury 42 97.46 Very High Very High Very High
Nervous System Injury 57 97.36 Very High Very High Very High
Disease 15 97.28 Very High Very High Very High
Cancer 94 96.60 Very High Very High Very High
Fibrosis 6 96.28 Very High Very High Very High
Breast Cancer 49 95.36 Very High Very High Very High
Metastasis 67 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is currently unclear which cell types in the spinal cord are involved in LPA production.
Regulation (involved) of Gene_expression (production) of LPA in spinal cord associated with spinal cord
1) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.42 Pain Relevance 0.32
LPA receptors and LPA receptor gene expression activates Rho in peripheral nerves [69-71], which suggests that LPA receptors might pathophysiologically activate Rho in neuropathic pain states of peripheral nerve injury.
Regulation (receptors) of Gene_expression (expression) of LPA receptor gene in peripheral nerve associated with nervous system injury, neuropathic pain and peripheral nerve injury
2) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.27 Pain Relevance 0.93
Many of us are now convinced that therapies targeting LPA biosynthesis and signalling are feasible for the treatment of devastating human diseases such as cancer, fibrosis and degenerative conditions.
Regulation (targeting) of Gene_expression (biosynthesis) of LPA associated with fibrosis, cancer and disease
3) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Abstract Doc Link PMC2989581 Disease Relevance 0.55 Pain Relevance 0.05
In the toluidine blue analysis, the injury-induced demyelination level in atx+/- mice was reduced to approximately half in WT mice (Figure 7), being consistent with the change of LPA production and neuropathic pain in atx+/- mice [10,11].
Regulation (change) of Gene_expression (production) of LPA associated with demyelination, injury and neuropathic pain
4) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.34 Pain Relevance 0.74
An important aim of future research will be evaluating the role of LPA3-related molecular mechanisms of LPA-induced LPA production in single or co-cultured specific cell types.
Regulation (role) of Gene_expression (production) of LPA-induced
5) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.67 Pain Relevance 0.47
These findings suggest that feed-forward LPA production is involved in LPA-induced neuropathic pain.



Regulation (involved) of Gene_expression (production) of LPA associated with neuropathic pain
6) Confidence 0.24 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2780384 Disease Relevance 0.46 Pain Relevance 0.62
However, the molecular mechanisms involved in the production of LPA and the direct role of LPA on bone cells at the bone metastatic site are still unknown.
Regulation (involved) of Gene_expression (production) of LPA
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0.83 Pain Relevance 0

General Comments

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