INT231392

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.19
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) extracellular space (Enpp2) extracellular region (Enpp2)
plasma membrane (Lpar1) cytoplasm (Lpar1) signal transducer activity (Lpar1)
Anatomy Link Frequency
blood 2
Enpp2 (Mus musculus)
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 28 99.36 Very High Very High Very High
Pain 35 96.16 Very High Very High Very High
Spinal cord 11 95.44 Very High Very High Very High
Sciatic nerve 11 91.40 High High
rheumatoid arthritis 1 88.48 High High
Neuropathic pain 53 86.32 High High
allodynia 20 63.92 Quite High
Thermal hyperalgesia 3 62.92 Quite High
substance P 11 50.56 Quite High
Glutamate 2 49.92 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.46 Very High Very High Very High
Demyelinating Disease 31 99.36 Very High Very High Very High
Pain 43 96.16 Very High Very High Very High
Nervous System Injury 28 91.68 High High
Rheumatoid Arthritis 1 88.48 High High
Neuropathic Pain 80 86.32 High High
Chronic Hepatitis 1 84.48 Quite High
Obesity 1 79.60 Quite High
Metastasis 57 76.64 Quite High
Injury 15 74.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the functional relevance of the catalytic activity of autotaxin in vivo was recently demonstrated from knockout mice studies showing that autotaxin is responsible for the levels of LPA in the blood circulation [8], [9].
autotaxin Positive_regulation (responsible) of Gene_expression (levels) of LPA in blood associated with targeted disruption
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.11 Pain Relevance 0.13
Autotaxin (or lysophospholipase D), which converts lysophosphatidyl choline (LPC) to LPA, is a key enzyme for LPA production [75].
lysophospholipase D Positive_regulation (enzyme) of Gene_expression (production) of LPA
2) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.08 Pain Relevance 0.80

General Comments

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