INT231411

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.18
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) DNA binding (HIVEP1)
cytoplasm (HIVEP1)
Anatomy Link Frequency
monocytes 4
plasma 2
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 3 85.40 High High
Bioavailability 4 83.52 Quite High
chemokine 6 37.84 Quite Low
cytokine 36 31.84 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
headache 10 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
methadone 5 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 616 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 15 68.08 Quite High
Renal Insufficiency 1 56.60 Quite High
Disease Progression 9 55.72 Quite High
Congenital Anomalies 3 55.20 Quite High
Immunodeficiency 14 50.12 Quite High
Infection 45 50.00 Quite Low
Cardiovascular Disease 10 40.16 Quite Low
Renal Disease 7 29.20 Quite Low
Myocardial Infarction 11 26.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiviral response was similar among all raltegravir groups (mean decreases in log10 HIV RNA level of 1.93, 1.98, 1.66, and 2.16 copies/mL 100, 200, 400, and 600 mg twice daily, respectively) and was significantly greater compared with placebo (mean decreases in log10 HIV RNA ?
Negative_regulation (decreases) of Transcription (level) of HIV associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.96 Pain Relevance 0
The antiviral response was similar among all raltegravir groups (mean decreases in log10 HIV RNA level of 1.93, 1.98, 1.66, and 2.16 copies/mL 100, 200, 400, and 600 mg twice daily, respectively) and was significantly greater compared with placebo (mean decreases in log10 HIV RNA ?
Negative_regulation (log10) of Transcription (level) of HIV associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504063 Disease Relevance 0.91 Pain Relevance 0
Sp1 and Sp4 are transcriptional activators, whereas Sp3 has been classified as a repressor of HIV-1 transcription.
Negative_regulation (repressor) of Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.03 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.42 Pain Relevance 0
The importance of the Sp sites also varies depending on the differentiation stage of the cell; in unstimulated monocytes, mutation of the Sp sites reduces LTR activity, whereas in MDMs, transcription of HIV and replication of SIVmac are abolished when these critical binding sites are knocked out [83-86].
Negative_regulation (abolished) of Transcription (transcription) of HIV in monocytes associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.03 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.34 Pain Relevance 0
The importance of the Sp sites also varies depending on the differentiation stage of the cell; in unstimulated monocytes, mutation of the Sp sites reduces LTR activity, whereas in MDMs, transcription of HIV and replication of SIVmac are abolished when these critical binding sites are knocked out [83-86].
Negative_regulation (abolished) of Transcription (transcription) of HIV in monocytes associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.03 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.46 Pain Relevance 0
Virologic failure was defined two ways: 1) if prior to week 24, it was defined as a reduction of plasma HIV-1 RNA level to <50 copies/mL on two consecutive occasions with a subsequent increase to ?
Negative_regulation (reduction) of Transcription (level) of HIV-1 in plasma associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.02 Published 2008 Journal AIDS Res Ther Section Body Doc Link PMC2365957 Disease Relevance 0.68 Pain Relevance 0.07
After 3TC is triphosphorylated, the principle mode of action is inhibition of HIV reverse transcription via viral DNA chain termination.
Negative_regulation (inhibition) of Transcription (transcription) of HIV associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.00 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2835563 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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