INT23146

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Context Info
Confidence 0.56
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 7.53
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Aprt) nucleolus (Aprt) nucleus (Aprt)
cellular_component (Aprt) cytoplasm (Aprt)
Anatomy Link Frequency
erythrocytes 1
Aprt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
pain flank 2 94.32 High High
lumbar region 3 83.00 Quite High
Pain 5 82.08 Quite High
tolerance 2 38.32 Quite Low
corticosteroid 4 19.72 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Calculi 2 99.76 Very High Very High Very High
Urolithiasis 15 99.64 Very High Very High Very High
Chronic Renal Failure 58 97.36 Very High Very High Very High
Recurrence 214 96.16 Very High Very High Very High
Sarcoidosis 6 95.72 Very High Very High Very High
Kidney Stones 2 95.64 Very High Very High Very High
Flank Pain 2 94.32 High High
Hydronephrosis 2 93.92 High High
Shock 3 93.28 High High
Balkan Nephropathy 4 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The adenine phosphoribosyltransferase activity in erythrocytes was partially deficient.
Negative_regulation (deficient) of adenine phosphoribosyltransferase in erythrocytes
1) Confidence 0.56 Published 1988 Journal Hinyokika Kiyo Section Abstract Doc Link 3041775 Disease Relevance 0.37 Pain Relevance 0.09
[A case of 2,8-dihydroxyadenine stones with a partial deficiency of adenine phosphoribosyltransferase].
Negative_regulation (deficiency) of adenine phosphoribosyltransferase
2) Confidence 0.56 Published 1988 Journal Hinyokika Kiyo Section Title Doc Link 3041775 Disease Relevance 0.37 Pain Relevance 0.09
Adenine phosphoribosyltransferase (APRT) enzyme activity was lowered to 0.8 nmol/hr/mg protein.
Negative_regulation (lowered) of Adenine phosphoribosyltransferase
3) Confidence 0.43 Published 2003 Journal Hinyokika Kiyo Section Abstract Doc Link 14518391 Disease Relevance 0.42 Pain Relevance 0.12
Thus, we diagnosed the illness as 2,8-DHA urolithiasis originating from APRT deficiency.
Negative_regulation (deficiency) of APRT associated with urolithiasis
4) Confidence 0.43 Published 2003 Journal Hinyokika Kiyo Section Abstract Doc Link 14518391 Disease Relevance 0.41 Pain Relevance 0.11
Adenine phosphoribosyltransferase (APRT) enzyme activity was lowered to 0.8 nmol/hr/mg protein.
Negative_regulation (lowered) of APRT
5) Confidence 0.43 Published 2003 Journal Hinyokika Kiyo Section Abstract Doc Link 14518391 Disease Relevance 0.42 Pain Relevance 0.12
To date in all countries but Japan, 2,8-DHA urolithiasis is observed only into homozygotic subjects with complete APRT deficiency.
Negative_regulation (deficiency) of APRT associated with urolithiasis
6) Confidence 0.32 Published 1989 Journal Chir Pediatr Section Abstract Doc Link 2698287 Disease Relevance 0.63 Pain Relevance 0.08
To date in all countries but Japan, 2,8-DHA urolithiasis is observed only into homozygotic subjects with complete APRT deficiency Commonly, its onset is observed in childhood often dramatically.
Negative_regulation (deficiency) of APRT associated with urolithiasis
7) Confidence 0.24 Published 1990 Journal Chir Pediatr Section Abstract Doc Link 2387000 Disease Relevance 0.63 Pain Relevance 0.08
Adenine phosphoribosyl-transferase deficiency
Negative_regulation (deficiency) of phosphoribosyl-transferase
8) Confidence 0.01 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 2.09 Pain Relevance 0
Very few patients with adenine phosphoribosyl-transferase deficiency and 2,8-dihydroxyadenine tubulointerstitial lesions present with ESRD of ‘unknown origin’ and no history of nephrolithiasis.
Negative_regulation (deficiency) of phosphoribosyl-transferase associated with chronic renal failure and kidney stones
9) Confidence 0.01 Published 2009 Journal Pediatr Nephrol Section Body Doc Link PMC2753770 Disease Relevance 2.19 Pain Relevance 0

General Comments

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