INT23147

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Context Info
Confidence 0.38
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 14.33
Pain Relevance 8.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (MRI1) cytosol (MRI1) small molecule metabolic process (MRI1)
nucleus (MRI1) cellular nitrogen compound metabolic process (MRI1) cytoplasm (MRI1)
Anatomy Link Frequency
cartilage 9
knee 3
spinal 2
plasma cells 1
nerve 1
MRI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 711 100.00 Very High Very High Very High
Inflammation 160 100.00 Very High Very High Very High
Osteoarthritis 604 99.98 Very High Very High Very High
spinal inflammation 135 99.48 Very High Very High Very High
metalloproteinase 42 99.36 Very High Very High Very High
Multiple sclerosis 352 98.98 Very High Very High Very High
Infliximab 102 98.72 Very High Very High Very High
Pain 344 96.28 Very High Very High Very High
corticosteroid 19 94.44 High High
cva 5 87.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 196 100.00 Very High Very High Very High
Disease 140 100.00 Very High Very High Very High
Recurrence 124 100.00 Very High Very High Very High
Brucella Infection 43 100.00 Very High Very High Very High
Knee Osteoarthritis 526 99.98 Very High Very High Very High
Appendicitis 49 99.20 Very High Very High Very High
Demyelinating Disease 388 98.98 Very High Very High Very High
Low Back Pain 254 98.56 Very High Very High Very High
Osteoarthritis 78 98.08 Very High Very High Very High
Hydrocephalus 2 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensitivity, specificity, positive and negative predictive value of MRI in detecting acute appendicitis will be calculated with corresponding 95% confidence intervals, by comparing the results of MRI, as read by trained radiologists and the MRI expert panel, with the final diagnosis assigned by the expert panel.
Negative_regulation (value) of MRI associated with appendicitis
1) Confidence 0.38 Published 2010 Journal BMC Emerg Med Section Body Doc Link PMC2978143 Disease Relevance 0.20 Pain Relevance 0.08
Sensitivity, specificity, and positive and negative predictive values of MRI-visible nerve involvement to findings of nerve involvement detected in the physical examination and pain drawing (Table 4)
Negative_regulation (values) of MRI-visible in nerve associated with pain and imagery
2) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2944219 Disease Relevance 0.69 Pain Relevance 0.96
However, this clearly indicates the avoidance of loops is necessary to reduce MRI related heating.
Negative_regulation (reduce) of MRI associated with imagery
3) Confidence 0.37 Published 2002 Journal Biomed Eng Online Section Body Doc Link PMC130994 Disease Relevance 0.45 Pain Relevance 0.10
These issues would need emphasis when developing IEC as an intervention to reduce MRI-related morbidity and mortality in the study communities.
Negative_regulation (reduce) of MRI
4) Confidence 0.36 Published 2005 Journal Malar J Section Body Doc Link PMC1262759 Disease Relevance 0.43 Pain Relevance 0
There was an improvement on his neurological findings and Gd-DTPA enhancement had been diminished on MRI.
Negative_regulation (diminished) of MRI
5) Confidence 0.34 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2387110 Disease Relevance 0.74 Pain Relevance 0.26
In spite of the received treatment, vesicular parasites persisted on the last MRI, and CSF was still inflammatory.


Negative_regulation (persisted) of MRI associated with inflammation and imagery
6) Confidence 0.33 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2841125 Disease Relevance 0.92 Pain Relevance 0.33
However, the specificity of MRI in the identification of nerve root involvement is reduced by the prevalence of degenerative changes of the spine in asymptomatic individuals [49].
Negative_regulation (reduced) of MRI in spine associated with imagery
7) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2661253 Disease Relevance 0.78 Pain Relevance 0.86
Similarly, using MRI, a significant decrease of inflammatory lesions already after 6 weeks of therapy [14] and ongoing improvement of spinal inflammation for up to 2 years [15,16] of continuous treatment have been reported.
Negative_regulation (decrease) of MRI in spinal associated with spinal inflammation, inflammation and imagery
8) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592781 Disease Relevance 1.18 Pain Relevance 1.06
For the planning of the experiments and the interpretation of the MRI sequences of the complex in vivo fluid oscillation, the biophysical model turned out to be a powerful tool to combine, compare and understand the imaging results in the environmental context.
Negative_regulation (interpretation) of MRI associated with imagery
9) Confidence 0.09 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0.06 Pain Relevance 0.07
We also conducted exploratory analyses to assess whether bone biomarkers were associated with cartilage loss on MRI in the BOKS sample.
Negative_regulation (loss) of MRI in cartilage associated with imagery
10) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.14 Pain Relevance 0.13
We assessed whether increased levels of each biomarker was predictive of subsequent cartilage loss on knee MRI (ascertained from baseline to 30 month visit).
Negative_regulation (loss) of MRI in knee associated with imagery
11) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.14 Pain Relevance 0.13
Intravenous methylprednisolone (IV-MP) is an established treatment for multiple sclerosis (MS) relapses, accompanied by rapid, though transient reduction of gadolinium enhancing (Gd+) lesions on brain MRI.
Negative_regulation (reduction) of MRI in brain associated with multiple sclerosis and recurrence
12) Confidence 0.07 Published 2006 Journal BMC Neurol Section Abstract Doc Link PMC1501038 Disease Relevance 0.63 Pain Relevance 0.22
Natalizumab, a recently re-approved drug for MS treatment, has been shown to reduce the numbers of CD19+ B cells and CD138+ plasma cells within the CSF [32] which correlated with the reduction of relapse rates as well as of the inflammatory disease activity on MRI.
Negative_regulation (reduction) of MRI in plasma cells associated with multiple sclerosis, inflammation, disease, imagery and recurrence
13) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.95 Pain Relevance 0.49
Reduction in MRI evidence of spinal inflammation had a strong correlation with the observed clinical improvement in infliximab-treated patients.
Negative_regulation (Reduction) of MRI in spinal associated with spinal inflammation, inflammation, infliximab and imagery
14) Confidence 0.04 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.67 Pain Relevance 0.73
Within the BOKS population, 80 subjects with MRI cartilage loss and 80 subjects without cartilage loss were selected for the purposes of this nested case control study.
Negative_regulation (loss) of MRI in cartilage associated with imagery
15) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.42 Pain Relevance 0.37
MRI findings for brucellosis were decreased signal intensity in the vertebral bodies on T1-weighted images, increased signal in the vertebral bodies on T2-weighted images, increase in signal in discs on T2 weighted images, loss of end-plate definition on T1 weighted images and contrast enhancement in the discs on T1-weighted images with godolinuium (figure 1) [20].
Negative_regulation (decreased) of MRI associated with brucella infection and imagery
16) Confidence 0.03 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1458347 Disease Relevance 0.35 Pain Relevance 0.18
Nonetheless, a number of studies have found plausible biologic associations with cartilage loss on MRI in this dataset, including relations to alignment [40], bone marrow lesions [41], and meniscal abnormalities [42].
Negative_regulation (loss) of MRI in cartilage associated with congenital anomalies and imagery
17) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.37 Pain Relevance 0.39
Among subjects with symptomatic knee OA, a single measurement of increased COMP predicted subsequent cartilage loss on MRI.
Negative_regulation (loss) of MRI in knee associated with imagery and osteoarthritis
18) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2212578 Disease Relevance 0.70 Pain Relevance 0.33
We assessed whether increased levels of each biomarker were predictive of subsequent cartilage loss on knee MRI (ascertained from baseline to visit at 30 months).
Spec (whether) Negative_regulation (loss) of MRI in knee associated with imagery
19) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0 Pain Relevance 0.05
It is further possible that other biomarkers that we did not measure could have a relation to MRI cartilage loss such as matrix metalloproteinase-3, high sensitive C-reactive protein, hyaluronan, CTX-I, keratan sulphate, matrillin-1, and cartilage intermediate layer protein.
Negative_regulation (loss) of MRI in cartilage associated with metalloproteinase and imagery
20) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0.45 Pain Relevance 0.41

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