INT231474

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.04
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBS1) extracellular region (THBS1) cell adhesion (THBS1)
structural molecule activity (THBS1)
Anatomy Link Frequency
chondrocytes 2
covering 1
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 52 92.40 High High
Osteoarthritis 20 58.00 Quite High
endometriosis 1 54.00 Quite High
Central nervous system 4 48.48 Quite Low
Gabapentin 4 43.76 Quite Low
Inflammation 6 27.36 Quite Low
ischemia 4 24.72 Low Low
agonist 7 7.52 Low Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 129 96.32 Very High Very High Very High
Metastasis 21 93.76 High High
Diabetes Mellitus 6 87.36 High High
Pancreatic Cancer 5 87.12 High High
Renal Cancer 1 82.20 Quite High
Carcinoma 8 75.60 Quite High
Glioblastoma 1 74.44 Quite High
Leukemia 4 71.64 Quite High
Increased Venous Pressure Under Development 4 68.96 Quite High
Skin Cancer 4 67.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using promoter assays, Northern blot and ChIP (chromatin immunoprecipitation) assays, we identified that E2F-1 could directly transactivate TSP1 expression by binding to its promoter, further expending TSP1's regulatory factors.


TSP1 Binding (binding) of
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.21 Pain Relevance 0
In addition, E2F-1 could also directly bind to the TSP1 promoter region covering ?
TSP1 Binding (bind) of in covering
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955548 Disease Relevance 0.14 Pain Relevance 0
To further verify E2F-1 binding sites in the promoter of TSP1, on the basis of TSP1-promoter (?
TSP1 Binding (binding) of
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
In this study, we found that E2F-1 could transactivate TSP1 promoter activity and TSP1 promoter region contains potential E2F-1 binding consensus sequences.
TSP1 Binding (binding) of
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.29 Pain Relevance 0
In chondrocytes, a TSP-CD47/IAP complex may associate with ?
TSP Binding (associate) of in chondrocytes
5) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374443 Disease Relevance 0 Pain Relevance 0.11
TSP-1, tumstatin, angiostatin, and 16K hPRL are strongly recommended.
TSP-1 Binding (recommended) of
6) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 1.04 Pain Relevance 0.03
This study was undertaken to establish whether CD47/IAP is expressed by human articular chondrocytes and to establish whether it and potential ligands such as TSP and SIRP?
TSP Binding (ligands) of in chondrocytes
7) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374443 Disease Relevance 0.36 Pain Relevance 0.03

General Comments

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