INT231507

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptprc, Tlr4) phosphatase activity (Ptprc) signal transduction (Tlr4)
intracellular (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
leukocytes 1
microglial cells 1
Ptprc (Mus musculus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 2 68.56 Quite High
cytokine 50 59.28 Quite High
Inflammatory response 2 37.76 Quite Low
Inflammation 30 5.00 Very Low Very Low Very Low
chemokine 19 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 142 99.96 Very High Very High Very High
Multiple Sclerosis 1 71.16 Quite High
Demyelinating Disease 2 68.56 Quite High
Autoimmune Disease 1 67.48 Quite High
Targeted Disruption 18 50.00 Quite Low
Injury 3 46.72 Quite Low
INFLAMMATION 36 37.76 Quite Low
Amyloid Plaque 11 32.16 Quite Low
Alzheimer's Dementia 12 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, immunoreactivity for CD45 (migratory leukocytes) in TLR4m AD mice was not different from that in TLR4w AD mice.
CD45 Binding (immunoreactivity) of TLR4m in leukocytes associated with disease
1) Confidence 0.21 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.22 Pain Relevance 0.06
These observations promoted us to investigate the effect of cross-linking CD45RB on LPS-induced p38 MAPK activity in microglial cells.
CD45RB Binding (linking) of LPS in microglial cells
2) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0

General Comments

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