INT231557

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 5.22
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
blood 6
chondrocytes 2
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 11 100.00 Very High Very High Very High
cytokine 110 99.98 Very High Very High Very High
Arthritis 144 97.92 Very High Very High Very High
Potency 80 97.92 Very High Very High Very High
Inflammation 121 92.56 High High
Inflammatory mediators 6 88.80 High High
Osteoarthritis 108 88.28 High High
antagonist 17 78.40 Quite High
rheumatoid arthritis 67 70.56 Quite High
fibrosis 1 67.12 Quite High
Disease Link Frequency Relevance Heat
Arthritis 158 97.92 Very High Very High Very High
Necrosis 4 97.00 Very High Very High Very High
Cancer 4 96.64 Very High Very High Very High
Stress 32 96.24 Very High Very High Very High
Obesity 211 93.68 High High
Hematological Disease 12 92.88 High High
INFLAMMATION 123 92.56 High High
Osteoarthritis 108 88.28 High High
Overweight 26 86.40 High High
Aging 4 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, the elevated concentration of leptin actually induced the phosphorylation of STAT 1?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT
1) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.68 Pain Relevance 0.04
By contrast, the phosphorylation of STAT 5A and 5B in leptin-stimulated chondrocytes remained unchanged compared with untreated cells (data not shown).
Neg (unchanged) Positive_regulation (unchanged) of Phosphorylation (phosphorylation) of STAT in chondrocytes
2) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.25 Pain Relevance 0.13
Although we did not directly evaluate inhibition of JAK2 or in vitro granulopoiesis in the rat, inhibition of arthritis, cytokines and neutrophilia in the AIA model were observed at plasma exposures that were well below the human JAK2 IC50 and effects on GM-CSF stimulated STAT phosphorylation in the rat whole blood assay.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of STAT in blood associated with cytokine and arthritis
3) Confidence 0.08 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.69 Pain Relevance 0.40
The potency and selectivity of CP-690,550 were therefore assessed in vitro in whole blood using intracellular flow cytometry to measure STAT phosphorylation.
Positive_regulation (measure) of Phosphorylation (phosphorylation) of STAT in blood associated with potency
4) Confidence 0.06 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.34
The in vitro potency and selectivity of CP-690,550 were determined using recombinant human kinases and whole blood cytokine induced STAT phosphorylation assays.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT in blood associated with cytokine and potency
5) Confidence 0.05 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.96 Pain Relevance 0.57
the phosphorylation of signal transducers and activators of transcription

(STAT) 1 and 3 as well as Janus kinase 1 (JAK1) and JAK2 in activated

Positive_regulation (activated) of Phosphorylation (phosphorylation) of STAT
6) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.36 Pain Relevance 0.38
the phosphorylation of signal transducers and activators of transcription

(STAT) 1 and 3 as well as Janus kinase 1 (JAK1) and JAK2 in activated

Positive_regulation (well) of Phosphorylation (phosphorylation) of STAT
7) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.30 Pain Relevance 0.32
AGE receptor binding can initiate important signalling pathways involving activation of protein kinase C [108, 165], tyrosine phosphorylation of Janus kinase (JAK)/signal transducers and activators of transcription (STAT) [66], recruitment of phosphotidylinositol 3' kinase to Ras, [30] and induction of oxidative stress cascades which lead toNF?
Positive_regulation (activation) of Phosphorylation (phosphorylation) of STAT associated with stress and kinase c
8) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.79 Pain Relevance 0.12
Even brief periods of mechanical stretch can induce rapid phosphorylation of JAK, STAT and glycoprotein 130 [23].
Positive_regulation (induce) of Phosphorylation (phosphorylation) of STAT
9) Confidence 0.01 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2862957 Disease Relevance 0.19 Pain Relevance 0.03

General Comments

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