INT231560

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.41
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A)
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 88 100.00 Very High Very High Very High
Inflammatory mediators 1 96.00 Very High Very High Very High
Central nervous system 21 93.84 High High
Inflammation 67 93.72 High High
Multiple sclerosis 16 85.60 High High
agonist 33 79.04 Quite High
chemokine 14 63.32 Quite High
antagonist 7 62.36 Quite High
COX2 1 47.80 Quite Low
Inflammatory response 6 33.56 Quite Low
Disease Link Frequency Relevance Heat
Infection 68 100.00 Very High Very High Very High
Inflammatory Bowel Disease 30 98.24 Very High Very High Very High
Disease 77 95.92 Very High Very High Very High
INFLAMMATION 69 95.60 Very High Very High Very High
Cold Sores 367 90.16 High High
Demyelinating Disease 23 85.60 High High
Colitis 8 67.56 Quite High
Cancer 236 66.36 Quite High
Viral Infection 8 58.32 Quite High
Apoptosis 38 56.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In absence of IL-23, colonic levels of proinflammatory cytokines, as TNF-alpha, IFN-gamma, and IL-6, are reduced, while Tregs colonic population is greater.
Negative_regulation (reduced) of Neg (absence) Gene_expression (absence) of IL-23 associated with cytokine
1) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.87 Pain Relevance 0.23
and induced IL-23 expression during the acute infection but decreased its expression during the later time points.
Negative_regulation (decreased) of Gene_expression (expression) of IL-23 associated with infection
2) Confidence 0.06 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.88 Pain Relevance 0.23
production of IL-12p40, IL-23, and IL-27p28 proteins, which was significantly reduced
Negative_regulation (reduced) of Gene_expression (production) of IL-23
3) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2367430 Disease Relevance 0.66 Pain Relevance 0.53

General Comments

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