INT231565

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.07
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (YWHAE) mitochondrion (YWHAE) protein targeting (YWHAE)
enzyme binding (YWHAE) cytoplasm (YWHAE)
Anatomy Link Frequency
stem cell 1
YWHAE (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 10 99.62 Very High Very High Very High
Nicotine 64 98.00 Very High Very High Very High
opioid receptor 2 97.10 Very High Very High Very High
Morphine 4 92.00 High High
opiate 10 86.68 High High
Dopamine 28 44.40 Quite Low
Nucleus accumbens 16 31.12 Quite Low
Etanercept 1 30.36 Quite Low
Bioavailability 7 16.96 Low Low
addiction 12 13.60 Low Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 146 100.00 Very High Very High Very High
Sepsis 1 99.98 Very High Very High Very High
Neutropenia 7 99.76 Very High Very High Very High
Fever 7 99.52 Very High Very High Very High
Recurrence 5 99.00 Very High Very High Very High
Myeloid Leukemia 58 96.24 Very High Very High Very High
Disease 25 96.04 Very High Very High Very High
Toxicity 19 93.48 High High
Vomiting 39 87.76 High High
Anorexia 7 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypomethylating agents may be effective therapy in additional roles, such as maintenance therapy after induction chemotherapy or up front therapy for elderly patients with AML not proceeding to transplant, maintenance therapy after allogeneic stem cell transplantation for MDS attempting to reduce risk of relapse, or combined with other agents for patients with MDS unresponsive to standard therapy.
Positive_regulation (unresponsive) of MDS in stem cell associated with myeloid leukemia, myelodysplastic syndromes and recurrence
1) Confidence 0.23 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2939768 Disease Relevance 0.92 Pain Relevance 0
The current assumption is that the MDS is easily triggered by a broad range of neurotoxins because it was not exposed to such toxins during its evolution (Nesse & Berridge 1997).
Positive_regulation (triggered) of MDS associated with myelodysplastic syndromes
2) Confidence 0.08 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0.20 Pain Relevance 0
-opioid receptors, and that the tobacco plant evolved nicotine to replace endogenous acetylcholine at cholinergic receptors, in the CNS and PNS (table 1), not to activate the MDS ‘downstream’.
Neg (not) Positive_regulation (activate) of MDS associated with peripheral nervous system, nicotine, myelodysplastic syndromes and opioid receptor
3) Confidence 0.08 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0.27 Pain Relevance 0.49
Most episodes of febrile neutropenia and sepsis occurred in MDS patients during the first or second cycle of therapy, when neutropenia due to both therapy and/or disease was present.
Positive_regulation (occurred) of MDS associated with neutropenia, myelodysplastic syndromes, disease, fever and sepsis
4) Confidence 0.04 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.68 Pain Relevance 0

General Comments

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