INT231567

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP1A2) oxidoreductase activity (CYP1A2) endoplasmic reticulum (CYP1A2)
enzyme binding (CYP1A2)
CYP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 9 96.00 Very High Very High Very High
opiate 5 51.20 Quite High
Nicotine 32 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
Nucleus accumbens 8 5.00 Very Low Very Low Very Low
addiction 7 5.00 Very Low Very Low Very Low
Ventral tegmentum 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
Paracetamol 5 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 3 62.96 Quite High
Myelodysplastic Syndromes 16 5.00 Very Low Very Low Very Low
Nicotine Addiction 11 5.00 Very Low Very Low Very Low
Cancer 9 5.00 Very Low Very Low Very Low
Bladder Cancer 8 5.00 Very Low Very Low Very Low
Vomiting 6 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Worm Infection 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Adenoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In two cell lines both deficient in NER and one expressing CYP1A2 and NAT2, 2,6-DMA and 3,5-DMA were cytotoxic at dose levels of 100 ?
Negative_regulation (deficient) of Gene_expression (one) of CYP1A2
1) Confidence 0.36 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.06 Pain Relevance 0.08
For several key enzymes, CYP1A2, CYP2A6, CYP2C19 and CYP2E1, these ratios were particularly low (?
Negative_regulation (low) of Gene_expression (enzymes) of CYP1A2
2) Confidence 0.20 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0 Pain Relevance 0.05

General Comments

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