INT23157

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 9
Disease Relevance 0.98
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 6
paw 4
spinal 2
Melm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 106 99.52 Very High Very High Very High
antagonist 5 96.80 Very High Very High Very High
opioid receptor 10 96.36 Very High Very High Very High
narcan 5 95.56 Very High Very High Very High
Enkephalin 59 94.84 High High
halothane 19 84.88 Quite High
Arthritis 1 82.72 Quite High
Pain 64 82.16 Quite High
Dorsal horn 35 80.68 Quite High
anesthesia 10 79.52 Quite High
Disease Link Frequency Relevance Heat
Arthritis 11 98.44 Very High Very High Very High
Nociception 44 98.12 Very High Very High Very High
Pain 60 82.16 Quite High
Paralysis 5 72.52 Quite High
Sprains And Strains 5 19.44 Low Low
Rheumatoid Arthritis 15 10.16 Low Low
Metastasis 10 8.52 Low Low
Cancer 5 7.88 Low Low
Cancer Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Raising the K+ concentration in the perfusing fluid from 2.4 to 40 mM, as well as moving the hind paws, produced a significant enhancement of MELM release which was (at least) as pronounced in arthritic as in control rats.
Positive_regulation (enhancement) of Localization (release) of MELM associated with arthritis
1) Confidence 0.45 Published 1988 Journal Pain Section Abstract Doc Link 3340418 Disease Relevance 0.42 Pain Relevance 0.44
Heating the tail resulted in an increase in MELM release from the whole spinal cord of intact as well as of cervically transected rats.
Positive_regulation (increase) of Localization (release) of MELM in spinal cord associated with spinal cord
2) Confidence 0.39 Published 1989 Journal Brain Res. Section Abstract Doc Link 2713703 Disease Relevance 0 Pain Relevance 0.38
It is concluded that noxious thermal stimuli can induce a segmental release of MELM, i.e., only within spinal zones receiving the nociceptive inputs.
Positive_regulation (induce) of Localization (release) of MELM in spinal associated with nociception
3) Confidence 0.39 Published 1989 Journal Brain Res. Section Abstract Doc Link 2713703 Disease Relevance 0.10 Pain Relevance 0.36
In both cases, the increase in MELM release took place 5-10 min after the treatment and was of short duration (5-10 min).
Positive_regulation (increase) of Localization (release) of MELM
4) Confidence 0.17 Published 1990 Journal Pain Section Abstract Doc Link 2388769 Disease Relevance 0.08 Pain Relevance 0.24
Thus, it is very likely that the enhanced release of MELM observed in the present study following stimulation of only one hind paw might participate in DNIC.
Positive_regulation (enhanced) of Localization (release) of MELM in paw
5) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731161 Disease Relevance 0.08 Pain Relevance 0.24
In whole spinal cord perifusates (Fig. 1A), MELM release was found to increase markedly when pinches were applied to either hind paw (mean increases: by 105.3±20.9 and 88.5±27.4% for the right and left hind paws, respectively) and then rapidly returned to the control values after the cessation of stimulation.
Positive_regulation (increase) of Localization (release) of MELM in spinal cord associated with spinal cord
6) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731161 Disease Relevance 0 Pain Relevance 0.23
We show here that a noxious mechanical stimulus applied either to the right or the left hind paw elicited a marked increase of MELM release during perifusion of either the whole spinal cord or the cervico-trigeminal area.
Positive_regulation (increase) of Localization (release) of MELM in paw associated with spinal cord
7) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731161 Disease Relevance 0 Pain Relevance 0.22
Here we show that, in the rat, a noxious mechanical stimulus applied to either the right or the left hind paw elicits a marked increase of MELM release during perifusion of either the whole spinal cord or the cervico-trigeminal area.
Positive_regulation (increase) of Localization (release) of MELM in spinal cord associated with spinal cord
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2731161 Disease Relevance 0.23 Pain Relevance 0.43
Perifusion for 30–45 min before collecting the first samples allowed the release of MELM to be stable for at least the following 180 min, corresponding to the whole perifusion [42].
Positive_regulation (stable) of Localization (release) of MELM
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731161 Disease Relevance 0.07 Pain Relevance 0.28

General Comments

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