INT231592

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.13
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADRA2B) cell-cell signaling (ADRA2B) signal transducer activity (ADRA2B)
Anatomy Link Frequency
ovary 1
ADRA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 218 100.00 Very High Very High Very High
Opioid 56 100.00 Very High Very High Very High
Central nervous system 19 100.00 Very High Very High Very High
adenocard 17 100.00 Very High Very High Very High
MU agonist 2 99.98 Very High Very High Very High
agonist 58 98.76 Very High Very High Very High
substance P 2 97.64 Very High Very High Very High
Glutamate 1 97.00 Very High Very High Very High
Neurotransmitter 5 96.24 Very High Very High Very High
potassium channel 2 83.12 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 59 72.56 Quite High
Bordatella Infection 1 44.72 Quite Low
Recurrence 13 44.40 Quite Low
Obesity 9 40.64 Quite Low
Stress 8 33.36 Quite Low
INFLAMMATION 3 24.56 Low Low
Schizophrenia 25 21.56 Low Low
Neurodegenerative Disease 5 20.72 Low Low
Disease 31 17.04 Low Low
Pain 55 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction of the incretins with their G-protein coupled receptor, which is expressed on pancreatic ?
G-protein coupled receptor Binding (interaction) of
1) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.13 Pain Relevance 0.23
G-protein-coupled receptors (GPCRsa) aAbbreviations: GPCR, G-protein-coupled receptor; AR, adenosine receptor; CNS, central nervous system; SEA, similarity ensemble approach; PDB, Protein Data Bank; WOMBAT, World of Molecular Bioactivity; CHO, Chinese hamster ovary; DMEM, Dulbecco’s modified Eagle medium; PKA, protein kinase A; DLS, dynamic light scattering. are a large family of transmembrane proteins that signal intracellularly after binding an extracellular ligand.
G-protein-coupled receptor Binding (binding) of in ovary associated with adenocard and central nervous system
2) Confidence 0.04 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC2865168 Disease Relevance 0 Pain Relevance 0.10
Fig. 2An opioid agonist binds to an opioid G-protein-coupled opioid receptor (A) activating the G protein complex by a GDP to GTP switch in the G?
G-protein-coupled opioid receptor Binding (binds) of associated with mu agonist, opioid receptor and opioid
3) Confidence 0.03 Published 2008 Journal Brain Section Body Doc Link PMC2367693 Disease Relevance 0 Pain Relevance 0.81
(Similar to most Class A GPCR’s the conformational state of Class B GPCR’s regulated by receptor-G-protein interaction [71], reflected in the higher agonist affinity at the G-protein coupled state (RG) compared with the uncoupled state (R).)
receptor-G-protein Binding (interaction) of associated with agonist
4) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0 Pain Relevance 0.05
In addition, it has affinity for both alpha-adrenergic1 and 2 and histaminic1 receptors.
alpha-adrenergic1 and 2 Binding (affinity) of
5) Confidence 0.02 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656329 Disease Relevance 0 Pain Relevance 0.04

General Comments

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