INT2316

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1977
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.84
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a5)
Anatomy Link Frequency
bile duct 1
livers 1
1A2 1
Ugt1a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 3 99.44 Very High Very High Very High
Morphine 13 95.84 Very High Very High Very High
Paracetamol 7 93.40 High High
dexamethasone 3 80.08 Quite High
Analgesic 1 40.60 Quite Low
Disease Link Frequency Relevance Heat
Hyperbilirubinemia 3 98.44 Very High Very High Very High
Jaundice 6 97.24 Very High Very High Very High
Pox Virus Infection 1 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, injection of bilirubin at subtoxic doses using a variety of regimens failed to produce detectable activation of UDPGT in intact or bile duct-ligated rats.
Positive_regulation (activation) of UDPGT in bile duct associated with bile
1) Confidence 0.67 Published 1977 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 403586 Disease Relevance 0.25 Pain Relevance 0.28
The data suggest that activation of UDPGT is of little, if any, significance in hyperbilirubinemia although the basis for increased excretion of morphine following bilirubin pretreatment has not been established.
Positive_regulation (activation) of UDPGT associated with hyperbilirubinemia and morphine
2) Confidence 0.58 Published 1977 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 403586 Disease Relevance 0.28 Pain Relevance 0.31
A decrease in cytochrome b5 content was accompanied by a compensatory increase in the activity of NADH-cytochrome b5 reductase.
Positive_regulation (increase) of b5
3) Confidence 0.54 Published 1996 Journal Folia Biol. (Praha) Section Abstract Doc Link 8971222 Disease Relevance 0 Pain Relevance 0.34
Addition of bilirubin in vitro to hepatic microsomes or 9,333 g supernatant activated UDP glucuronyltransferase activity (UDPGT) for p-nitrophenol of livers from Sprague-Dawley rats, Wistar rats, icteric Gunn rats and nonicteric Gunn rats.
Positive_regulation (activated) of UDPGT in livers associated with jaundice
4) Confidence 0.39 Published 1977 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 403586 Disease Relevance 0.22 Pain Relevance 0.19
Of these, P450 2E1, 1A2, and 3A4 showed substantial activity, with respective Km and Vmax values of 680 microM and 330 pmol/(min.mg) for P450 2E1 (with added cytochrome b5), 3430 microM and 74 pmol/(min.mg) for P450 1A2, and 280 microM and 130 pmol/(min.mg) for P450 3A4.
Positive_regulation (added) of b5 in 1A2
5) Confidence 0.25 Published 1993 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8374050 Disease Relevance 0.09 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox