INT231621

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Il17a) extracellular region (Il6, Il17a)
Anatomy Link Frequency
T cells 2
Il6 (Mus musculus)
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 78.12 Quite High
Inflammation 8 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 32 81.52 Quite High
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 8 5.00 Very Low Very Low Very Low
Weight Loss 6 5.00 Very Low Very Low Very Low
Autoimmune Disease 5 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Immune System Diseases 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6–dependent spontaneous proliferation is required for the induction of colitogenic IL-17–producing CD8+ T cells

We propose a novel role for interleukin (IL) 6 in inducing rapid spontaneous proliferation (SP) of naive CD8+ T cells, which is a crucial step in the differentiation of colitogenic CD8+ T cells.

IL-6 Positive_regulation (required) of Positive_regulation (induction) of IL-17 in T cells
1) Confidence 0.15 Published 2008 Journal The Journal of Experimental Medicine Section Title Doc Link PMC2373835 Disease Relevance 0.19 Pain Relevance 0.04

General Comments

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