INT231732

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) response to stress (Tnfsf11)
Anatomy Link Frequency
synovium 2
Tnfrsf11a (Mus musculus)
Tnfsf11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 62 99.52 Very High Very High Very High
cytokine 16 95.00 High High
Inflammation 39 94.60 High High
agonist 19 83.68 Quite High
rheumatoid arthritis 10 69.24 Quite High
Potency 6 39.84 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 127 99.52 Very High Very High Very High
INFLAMMATION 39 94.60 High High
Disease 5 89.76 High High
Experimental Arthritis 5 81.88 Quite High
Rheumatoid Arthritis 10 69.24 Quite High
Osteoporosis 1 67.72 Quite High
Synovitis 6 64.32 Quite High
Hypercalcemia 2 51.28 Quite High
Diabetes Mellitus 6 30.08 Quite Low
Obesity 10 14.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, administration of osteoprotegerin, which prevents the binding of RANKL to RANK, decreased arthritis-induced bone loss [65], suggesting that TZDs may prevent bone loss, at least in part, by decreasing the production of inflammatory cytokines in inflamed synovium.
Negative_regulation (prevents) of RANK Binding (binding) of RANKL in synovium associated with inflammation, cytokine and arthritis
1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.03 Pain Relevance 0.48

General Comments

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