INT23174

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Context Info
Confidence 0.72
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 35.49
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP3) signal transduction (NLRP3) cytoplasm (NLRP3)
Anatomy Link Frequency
cones 5
Lymphocytes 2
THP-1 2
T cells 2
dorsal 1
NLRP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 1 100.00 Very High Very High Very High
antagonist 58 99.96 Very High Very High Very High
Dopamine 2 99.60 Very High Very High Very High
chemokine 5 98.28 Very High Very High Very High
cytokine 155 97.76 Very High Very High Very High
Inflammation 379 97.52 Very High Very High Very High
Migraine 11 96.94 Very High Very High Very High
Herpes zoster virus 2 96.68 Very High Very High Very High
depression 5 96.52 Very High Very High Very High
Arthritis 70 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 344 100.00 Very High Very High Very High
Leukostasis 64 99.08 Very High Very High Very High
Diabetic Retinopathy 376 99.00 Very High Very High Very High
Gallbladder Disease 16 98.96 Very High Very High Very High
Diabetes Mellitus 259 98.68 Very High Very High Very High
Shock 86 98.24 Very High Very High Very High
Disease 277 98.16 Very High Very High Very High
Crystal Associated Disease 9 98.12 Very High Very High Very High
Adhesions 36 97.78 Very High Very High Very High
INFLAMMATION 435 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, we could not detect the Nalp3 protein in HCE-T cells with the antibody that detected Nalp3 in THP-1 cells (data not shown).
Neg (not) Gene_expression (detect) of Nalp3 in THP-1
1) Confidence 0.72 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
as the principal consequence of CIAS1 mutations leading to the manifestation of the clinical disease, the CASP1 mutation appears to exert its pro-inflammatory effect by engaging RIP2, resulting in excessive activation of NF-?
Gene_expression (mutations) of CIAS1 associated with inflammation and disease
2) Confidence 0.67 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.13 Pain Relevance 0.14
In addition, I have presented my clinical experiences and research reports to introduce cases of migraine for which prophylactic therapy was indicated, to hypothesize the mechanisms of the prophylatic activity of specific drugs (e.g., anti-convulsants, anti-depressants, beta-blockers, AII antagonists, Ca channel blockers, leukotriene receptor antagonists, statins, anti-herpes zoster virus drugs) for their prophylactic effect on migraine, and to determine drug regimens.
Gene_expression (depressants) of AII associated with beta blocker, antagonist, migraine and herpes zoster virus
3) Confidence 0.66 Published 2009 Journal Brain Nerve Section Abstract Doc Link 19882936 Disease Relevance 0.85 Pain Relevance 1.01
Mutations were not found in the coding regions of MVK, TNFRSF1A, and NLRP3 (previously NALP3/CIAS1) making the diagnoses of Hyper IgD syndrome, TNF receptor associated periodic syndrome (TRAPS), and Muckle Wells/Familial Cold Urticaria all unlikely.
Gene_expression (previously) of CIAS1 associated with cryopyrin-associated periodic syndromes, tumor necrosis factor receptor-associated periodic syndrome and syndrome
4) Confidence 0.65 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.77 Pain Relevance 0.18
Mutations were not found in the coding regions of MVK, TNFRSF1A, and NLRP3 (previously NALP3/CIAS1) making the diagnoses of Hyper IgD syndrome, TNF receptor associated periodic syndrome (TRAPS), and Muckle Wells/Familial Cold Urticaria all unlikely.
Gene_expression (/) of CIAS1 associated with cryopyrin-associated periodic syndromes, tumor necrosis factor receptor-associated periodic syndrome and syndrome
5) Confidence 0.65 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.76 Pain Relevance 0.18
At initiation of the attack, plasma ACTH, AVP, norepinephrine and prostaglandin E2 were markedly elevated, whereas dopamine was undetectable.
Gene_expression (elevated) of AVP in plasma associated with dopamine
6) Confidence 0.65 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2837885 Disease Relevance 0.86 Pain Relevance 0.22
A six point concentration: response curved of the contractile effect of angiotensin II (AII) on helically-cut strips of human chorionic plate artery strips were established at final concentrations of between 10(-14) to 10(-9) M.
Gene_expression (effect) of AII in artery
7) Confidence 0.65 Published 1989 Journal West Afr J Med Section Abstract Doc Link 2486765 Disease Relevance 0.21 Pain Relevance 0.15
However, as compared to the 6 h samples, their mRNA expression level recovered 24 h after irradiation in such a way that the expression levels of Nalp3 and Nalp10 became significantly higher than those measured from non-exposed control cells (Figure 4B).
Gene_expression (expression) of Nalp3
8) Confidence 0.63 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.09 Pain Relevance 0
Cryopyrin is present mainly in neutrophil cells and chondrocytes explaining the target organs of these diseases.


Gene_expression (present) of Cryopyrin in neutrophil associated with disease
9) Confidence 0.60 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 1.43 Pain Relevance 0.28
It has been proposed that these mutations have a gain of function effect, leading to spontaneous oligorimerization of NALP3 subunits around mutated NACHT domains and subsequent caspase-1 activation resulting in an excessive and inappropriate IL-1?
Gene_expression (subunits) of NALP3
10) Confidence 0.59 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.56 Pain Relevance 0
Experimental data accumulated from micropuncture studies, analyses of isolated glomeruli in vitro, and glomerular mesangial cell cultures also support the hypothesis that AII-stimulated production of vasodilatory prostaglandins attenuates AII-induced constriction at the glomerular level as well.
Gene_expression (production) of AII in mesangial cell
11) Confidence 0.58 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092664 Disease Relevance 0.16 Pain Relevance 0.16
However, the expression of the Nalp3 sensor was more than 20 fold higher in HCE-T cells than in the PRK samples.
Gene_expression (expression) of Nalp3 in T cells
12) Confidence 0.56 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
While the expression of Nalp3 and Nalp10 was higher in HCE-T cells, ASC and caspase-1 showed higher transcription levels in the primary cells.
Gene_expression (expression) of Nalp3 in T cells
13) Confidence 0.56 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0.05 Pain Relevance 0.08
However, we could not detect the expression of Nalp3 protein while we detected the expression of a shorter isoform of Nalp1.
Gene_expression (expression) of Nalp3
14) Confidence 0.56 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.07 Pain Relevance 0
At the protein level, we detected a short isoform of Nalp1 and its expression changed in a similar way as its RNA expression, but we could not detect Nalp3 protein.
Neg (not) Gene_expression (detect) of Nalp3
15) Confidence 0.56 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0.12
On the other hand, we could not detect the Nalp3 protein in HCE-T cells with the antibody that detected Nalp3 in THP-1 cells (data not shown).
Gene_expression (detected) of Nalp3 in THP-1
16) Confidence 0.55 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
Single nucleotide polymorphisms (SNPs) in NLRP3 are associated with decreased NLRP3 expression and hypoproduction of interleukin (IL)-1beta.
Gene_expression (expression) of NLRP3
17) Confidence 0.47 Published 2009 Journal Drugs Today Section Abstract Doc Link 20011700 Disease Relevance 0.61 Pain Relevance 0
Mutations were not found in the coding regions of MVK, TNFRSF1A, and NLRP3 (previously NALP3/CIAS1) making the diagnoses of Hyper IgD syndrome, TNF receptor associated periodic syndrome (TRAPS), and Muckle Wells/Familial Cold Urticaria all unlikely.
Gene_expression (previously) of NLRP3 associated with cryopyrin-associated periodic syndromes, tumor necrosis factor receptor-associated periodic syndrome and syndrome
18) Confidence 0.42 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.77 Pain Relevance 0.18
Mutations were not found in the coding regions of MVK, TNFRSF1A, and NLRP3 (previously NALP3/CIAS1) making the diagnoses of Hyper IgD syndrome, TNF receptor associated periodic syndrome (TRAPS), and Muckle Wells/Familial Cold Urticaria all unlikely.
Gene_expression (previously) of NALP3 associated with cryopyrin-associated periodic syndromes, tumor necrosis factor receptor-associated periodic syndrome and syndrome
19) Confidence 0.42 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.77 Pain Relevance 0.18
Mutations were not found in the coding regions of MVK, TNFRSF1A, and NLRP3 (previously NALP3/CIAS1) making the diagnoses of Hyper IgD syndrome, TNF receptor associated periodic syndrome (TRAPS), and Muckle Wells/Familial Cold Urticaria all unlikely.
Gene_expression (/) of NLRP3 associated with cryopyrin-associated periodic syndromes, tumor necrosis factor receptor-associated periodic syndrome and syndrome
20) Confidence 0.42 Published 2008 Journal Cases J Section Body Doc Link PMC2612653 Disease Relevance 1.78 Pain Relevance 0.18

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