INT231740

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cartilage 1
T cell 1
LOC690550 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 48 99.40 Very High Very High Very High
cytokine 30 97.20 Very High Very High Very High
Inflammation 26 97.12 Very High Very High Very High
Arthritis 102 93.32 High High
antagonist 6 77.76 Quite High
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 52 99.44 Very High Very High Very High
Rheumatoid Arthritis 48 99.40 Very High Very High Very High
Arthritis 108 97.36 Very High Very High Very High
Pressure And Volume Under Development 30 48.40 Quite Low
Cancer 4 44.64 Quite Low
Necrosis 4 44.16 Quite Low
Autoimmune Disease 2 40.80 Quite Low
INFLAMMATION 30 29.48 Quite Low
Erythema 10 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CP-690550, a potent inhibitor of JAK3, reduced the clinical and histological manifestations of joint inflammation, including bone and cartilage damage, when administered therapeutically in murine CIA and rat AA.
Negative_regulation (inhibitor) of CP-690550 in cartilage associated with inflammation and arthritis
1) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.15 Pain Relevance 0.66
CP-690550 is a small molecule inhibitor of Janus kinase 3 (JAK3), a critical enzyme in the signaling pathway of multiple cytokines (interleukin (IL)-2, -7, -15 and -21) that are important in various T cell functions including development, activation and homeostasis.
Negative_regulation (inhibitor) of CP-690550 in T cell associated with cytokine
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374467 Disease Relevance 0.35 Pain Relevance 0.20

General Comments

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