INT231741

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.14
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Blood 2
LOC690550 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 12 99.08 Very High Very High Very High
Arthritis 306 99.00 Very High Very High Very High
rheumatoid arthritis 144 98.64 Very High Very High Very High
anesthesia 6 96.68 Very High Very High Very High
cytokine 90 96.08 Very High Very High Very High
Inflammatory response 6 93.72 High High
Inflammation 78 87.36 High High
methotrexate 12 37.24 Quite Low
antagonist 18 14.60 Low Low
Disease Link Frequency Relevance Heat
Arthritis 324 99.00 Very High Very High Very High
INFLAMMATION 90 98.68 Very High Very High Very High
Rheumatoid Arthritis 144 98.64 Very High Very High Very High
Hypersensitivity 18 94.88 High High
Disease 156 93.00 High High
Pressure And Volume Under Development 90 91.32 High High
Erythema 30 66.48 Quite High
Adverse Drug Reaction 6 43.80 Quite Low
Sprains And Strains 6 42.56 Quite Low
Hypertrophy 6 19.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy produced by CP-690550 in the rodent models of arthritis may result from its ability to affect signaling of a number of cytokines including IL-2, -7, -15 and -21 as a consequence of JAK3 inhibition [5].
Gene_expression (produced) of CP-690550 associated with cytokine and arthritis
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.00 Pain Relevance 0.38
Blood samples were immediately taken via cardiac puncture and serum analyzed for CP-690550 levels.
Spec (analyzed) Gene_expression (levels) of CP-690550 in Blood
2) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.65 Pain Relevance 0.12
Blood samples were immediately taken via cardiac puncture and serum analyzed for CP-690550 levels.
Spec (analyzed) Gene_expression (levels) of CP-690550 in Blood
3) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.83 Pain Relevance 0.16
As early as 3 days post-implantation of pumps, mice receiving both high and low doses of CP-690550 exhibited significant reductions in the clinical score vs vehicle (Figure 2).
Gene_expression (reductions) of CP-690550
4) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.49 Pain Relevance 0.18
CP-690550 was synthesized in-house and the enzyme specificity of this compound has been previously described [5].
Gene_expression (synthesized) of CP-690550
5) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.07 Pain Relevance 0.49
CP-690550 doses/exposures that produced effects in this model are consistent with those demonstrating immune suppression in other murine models including delayed-type hypersensitivity and cardiac allograft transplantation [5,6].
Gene_expression (produced) of CP-690550 associated with hypersensitivity
6) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.10 Pain Relevance 0.39

General Comments

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