INT231744

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Jak3) intracellular (Jak3) kinase activity (Jak3)
cytoplasm (Jak3)
Jak3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 95.60 Very High Very High Very High
Arthritis 51 81.20 Quite High
methotrexate 2 71.76 Quite High
rheumatoid arthritis 24 65.76 Quite High
Inflammation 13 60.56 Quite High
antagonist 3 49.12 Quite Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 3 87.32 High High
Arthritis 54 81.20 Quite High
Adverse Drug Reaction 1 78.32 Quite High
Disease 26 73.36 Quite High
Rheumatoid Arthritis 24 65.76 Quite High
INFLAMMATION 15 60.56 Quite High
Necrosis 2 48.12 Quite Low
Cancer 2 47.76 Quite Low
Synovitis 1 14.40 Low Low
Pressure And Volume Under Development 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, JAK3 expression has been shown to decrease in the synovial tissue biopsies from active rheumatoid arthritics receiving and responding to DMARD therapy [8].
Negative_regulation (decrease) of Gene_expression (expression) of JAK3
1) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.90 Pain Relevance 0.43

General Comments

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