INT231748

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.95 Pain Relevance 0.36

extracellular space (Il6) extracellular region (Il6)

LOC690550 (Rattus norvegicus) Il6 (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 51 93.60 Inflammatory mediators 2 89.12 cytokine 15 84.64 Inflammation 13 49.48 rheumatoid arthritis 24 41.76 Inflammatory response 1 34.56 antagonist 3 5.00 methotrexate 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 3 97.36 Arthritis 54 93.60 Disease 26 89.84 INFLAMMATION 15 88.72 Pressure And Volume Under Development 15 49.84 Rheumatoid Arthritis 24 41.76 Erythema 5 5.00 Necrosis 2 5.00 Cancer 2 5.00 Sprains And Strains 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, both CP-690550 (78% reduction vs control) and the anti-TNF mAb (68% reduction vs control) significantly reduced serum IL-6 levels.

CP-690550 Negative_regulation (reduced) of IL-6

1) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.95 Pain Relevance 0.36

General Comments

This test has worked.