INT231750

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Jak3) intracellular (Jak3) kinase activity (Jak3)
cytoplasm (Jak3)
LOC690550 (Rattus norvegicus)
Jak3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 93.92 High High
methotrexate 4 82.84 Quite High
rheumatoid arthritis 48 76.84 Quite High
Arthritis 102 62.32 Quite High
antagonist 6 60.20 Quite High
Inflammation 26 41.68 Quite Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 6 98.40 Very High Very High Very High
Adverse Drug Reaction 2 89.40 High High
Rheumatoid Arthritis 48 76.84 Quite High
Disease 52 73.08 Quite High
Arthritis 108 62.32 Quite High
Necrosis 4 59.20 Quite High
Cancer 4 58.84 Quite High
INFLAMMATION 30 41.68 Quite Low
Synovitis 2 25.48 Quite Low
Pressure And Volume Under Development 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CP-690550 is a small molecule inhibitor of the tyrosine kinase Janus kinase 3 (JAK3), an enzyme that is associated with the common gamma chain (?
CP-690550 Negative_regulation (inhibitor) of JAK3
1) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.67 Pain Relevance 0.27
CP-690550 is a small molecule inhibitor of the tyrosine kinase Janus kinase 3 (JAK3), an enzyme that is associated with the common gamma chain (?
CP-690550 Negative_regulation (inhibitor) of Janus kinase 3
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.62 Pain Relevance 0.25

General Comments

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