INT231752

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Il6) extracellular region (TNF, Il6) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 99.56 Very High Very High Very High
Arthritis 51 94.88 High High
Inflammatory mediators 2 76.00 Quite High
rheumatoid arthritis 24 60.80 Quite High
Inflammatory response 1 53.60 Quite High
Inflammation 13 36.36 Quite Low
antagonist 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 26 96.92 Very High Very High Very High
Arthritis 54 94.88 High High
Hypersensitivity 3 84.24 Quite High
INFLAMMATION 15 75.60 Quite High
Rheumatoid Arthritis 24 60.80 Quite High
Pressure And Volume Under Development 15 36.72 Quite Low
Erythema 5 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of anti-TNF on IL-6 are consistent with other reports in which inhibition of TNF action, either via genetic ablation of its receptor [20] or via anti-TNF mAb [21,22] were found to down-modulate levels of IL-6.
anti-TNF Regulation (effects) of IL-6
1) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 0.99 Pain Relevance 0.41

General Comments

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