INT231756

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4, HMOX1, TLR4) intracellular (TLR4, TLR4) cytoplasm (TLR4, TLR4)
plasma membrane (TLR4, TLR4) small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1)
TLR4 (Homo sapiens)
HMOX1 (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 7 99.44 Very High Very High Very High
Inflammation 16 61.68 Quite High
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 79 100.00 Very High Very High Very High
INFLAMMATION 24 99.44 Very High Very High Very High
Shock 4 98.00 Very High Very High Very High
Stress 1 57.36 Quite High
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Rheumatic Diseases 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low
Uveitis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Autoimmune Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that upregulated TLR4 is associated with HO-1 reduction in PBMCs from patients with Beh├žet's disease, leading to augmented inflammatory responses.



Positive_regulation (upregulated) of TLR4 Positive_regulation (leading) of HO-1 Binding (associated) of TLR4 associated with inflammatory response and disease
1) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374472 Disease Relevance 0.96 Pain Relevance 0.11

General Comments

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