INT231757

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.37
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4, HMOX1) small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1)
intracellular (TLR4) enzyme binding (HMOX1) transmembrane transport (HMOX1)
Anatomy Link Frequency
immune system 2
TLR4 (Homo sapiens)
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 99.12 Very High Very High Very High
rheumatoid arthritis 10 55.76 Quite High
Inflammatory response 7 46.00 Quite Low
ischemia 1 8.48 Low Low
Infliximab 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 99.12 Very High Very High Very High
Disease 79 98.48 Very High Very High Very High
Shock 4 67.84 Quite High
Rheumatoid Arthritis 10 55.76 Quite High
Cancer 2 51.04 Quite High
Necrosis 2 50.56 Quite High
Lung Injury 2 18.72 Low Low
Reperfusion Injury 1 9.24 Low Low
Cv Unclassified Under Development 1 8.48 Low Low
Rheumatic Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the data presented, we hypothesize that HSP60 stimulates not only antigen-specific autoimmune responses but also the innate immune system through constitutively over-expressed TLR4, which mediates HO-1 reduction in PBMCs, leading to inflammation in BD.
TLR4 Positive_regulation (mediates) of Negative_regulation (reduction) of HO-1 in immune system associated with inflammation and disease
1) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.37 Pain Relevance 0.15

General Comments

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