INT23176

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.06
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Pdpn) embryo development (Pdpn) cell proliferation (Pdpn)
signal transduction (Pdpn) cell adhesion (Pdpn) plasma membrane (Pdpn)
Anatomy Link Frequency
stroma 1
skeletal muscle 1
platelet 1
PNS 1
Pdpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 3 99.96 Very High Very High Very High
Angina 11 98.72 Very High Very High Very High
Neuritis 8 95.48 Very High Very High Very High
ischemia 64 86.20 High High
alcohol 1 80.64 Quite High
anesthesia 1 71.60 Quite High
chemokine 6 61.84 Quite High
depression 4 61.84 Quite High
Inflammation 4 49.76 Quite Low
Osteoarthritis 4 36.72 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 1 99.98 Very High Very High Very High
Cv General 3 Under Development 9 98.72 Very High Very High Very High
Cervical Cancer 3 97.44 Very High Very High Very High
Hepatocellular Cancer 5 96.04 Very High Very High Very High
Volume Depletion And Dehydration 2 95.80 Very High Very High Very High
Experimental Autoimmune Neuritis 8 95.48 Very High Very High Very High
Pressure And Volume Under Development 1 94.52 High High
Cirrhosis 2 93.88 High High
Injury 57 90.20 High High
Infection 2 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Carvalho et al. investigated the clinical and pathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer.
Gene_expression (expression) of podoplanin in stroma associated with cervical cancer
1) Confidence 0.75 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020329 Disease Relevance 1.39 Pain Relevance 0.03
Among these 4 identified target genes, podoplanin (Pdpn) is a transmembrane glycoprotein and is expressed in many normal human tissues including the skeletal muscle [33].
Gene_expression (expressed) of Pdpn in skeletal muscle
2) Confidence 0.71 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.28 Pain Relevance 0.06
The procedures and methods that consistently produced the best light and electron microscopic preservation of the E11-E13 rat CNS are described.
Gene_expression (produced) of E11
3) Confidence 0.58 Published 1990 Journal J Electron Microsc Tech Section Abstract Doc Link 2391564 Disease Relevance 0.44 Pain Relevance 0.11
In monitoring the target genes of miR-21 in the expression array at 1, 3, 7, 14 d after reperfusion, with persistent expression throughout the experiment, we detected the same 4 persistently downregulated target genes (Nqo1, Pdpn, CXCL3, and Rad23b) with the prediction algorithms miRanda and RNAhybrid, but no target gene was revealed with PicTar, TargetScanS, and MirTarget2.


Gene_expression (detected) of Pdpn
4) Confidence 0.55 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2894749 Disease Relevance 0.36 Pain Relevance 0.10
Our data suggest a pathogenic role of IgM antibodies against HNK adhesion carbohydrate epitope expressing PNS proteins P0, MAG and PMP-22.
Gene_expression (expressing) of carbohydrate epitope in PNS associated with peripheral nervous system and adhesions
5) Confidence 0.01 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8982118 Disease Relevance 0.89 Pain Relevance 0.72
Patients with unstable complex lesions had a fivefold higher expression of the platelet activation epitope CD63 than patients with stable angina.
Gene_expression (expression) of activation epitope in platelet associated with angina
6) Confidence 0.00 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 11024397 Disease Relevance 0.69 Pain Relevance 0.62

General Comments

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