INT231760

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, HMOX1) signal transduction (TNF, HMOX1) transmembrane transport (HMOX1)
oxidoreductase activity (HMOX1) cell death (HMOX1) plasma membrane (TNF)
Anatomy Link Frequency
monocytes 2
TNF (Homo sapiens)
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 2 60.72 Quite High
Inflammatory response 7 50.80 Quite High
Inflammation 16 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 79 83.84 Quite High
INFLAMMATION 24 50.44 Quite High
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Rheumatic Diseases 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low
Uveitis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Autoimmune Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our previous study [26] we demonstrated that TNF enhances HO-1 mRNA degradation, resulting in a reduction in HO-1 expression in human monocytes.
TNF Positive_regulation (enhances) of Protein_catabolism (degradation) of HO-1 mRNA in monocytes
1) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.41 Pain Relevance 0.06

General Comments

This test has worked.

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