INT231761

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.20
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, HMOX1) signal transduction (TNF, HMOX1) transmembrane transport (HMOX1)
oxidoreductase activity (HMOX1) cell death (HMOX1) plasma membrane (TNF)
Anatomy Link Frequency
monocytes 1
TNF (Homo sapiens)
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 7 97.16 Very High Very High Very High
Inflammation 16 84.96 Quite High
ischemia 1 66.96 Quite High
cytokine 1 14.08 Low Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 97.16 Very High Very High Very High
Disease 79 96.24 Very High Very High Very High
Lung Injury 2 77.20 Quite High
Reperfusion Injury 1 67.72 Quite High
Cv Unclassified Under Development 1 66.96 Quite High
Rheumatic Diseases 4 60.56 Quite High
Autoimmune Disease 2 38.84 Quite Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our previous study [26] we showed that TNF suppresses HO-1 expression levels in human peripheral monocytes, thereby accelerating inflammatory responses; this suggests that excessive TNF levels contribute to defective HO-1 expression.
TNF Negative_regulation (suppresses) of HO-1 in monocytes associated with inflammatory response
1) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.20 Pain Relevance 0.12

General Comments

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