INT231762

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.68
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4, HMOX1) small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1)
intracellular (TLR4) enzyme binding (HMOX1) transmembrane transport (HMOX1)
TLR4 (Homo sapiens)
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 7 85.16 High High
Inflammation 16 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 79 99.40 Very High Very High Very High
INFLAMMATION 24 84.80 Quite High
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low
Rheumatic Diseases 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low
Uveitis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Autoimmune Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because LPS (a TLR4 ligand) has been shown to suppress interleukin-10-dependent HO-1 expression in human PBMCs [29], it is plausible that excessively expressed TLR4 contributes to defective HO-1 expression in PBMCs from BD patients.
TLR4 Positive_regulation (contributes) of Gene_expression (expression) of HO-1 associated with disease
1) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.68 Pain Relevance 0.04

General Comments

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