INT231763

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HSPD1, TLR2) unfolded protein binding (HSPD1) mitochondrion (HSPD1)
intracellular (TLR2) cytosol (HSPD1) signal transduction (TLR2)
HSPD1 (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 32 84.24 Quite High
cytokine 2 73.24 Quite High
rheumatoid arthritis 20 58.20 Quite High
ischemia 2 53.28 Quite High
Inflammatory response 14 5.00 Very Low Very Low Very Low
Infliximab 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 158 99.48 Very High Very High Very High
Autoimmune Disease 4 98.00 Very High Very High Very High
INFLAMMATION 48 84.24 Quite High
Rheumatic Diseases 8 66.88 Quite High
Rheumatoid Arthritis 20 58.20 Quite High
Targeted Disruption 4 55.52 Quite High
Cv Unclassified Under Development 2 53.28 Quite High
Reperfusion Injury 2 52.56 Quite High
Hemophagocytic Lymphohistiocytosis 2 37.88 Quite Low
Lung Injury 4 33.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because HSP60 has been implicated in the pathogenesis of BD [17], levels of mRNA for TLR2 and TLR4 (both of which recognize HSP60 as a ligand) were examined in PBMCs and PMNs from patients with BD (Figure 2).
HSP60 Binding (recognize) of TLR2 associated with disease
1) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.62 Pain Relevance 0
In the present study, expression levels of TLR2 and TLR4 were examined because both TLRs recognize HSP60 as ligands [10,11].
HSP60 Spec (examined) Binding (recognize) of TLR2
2) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.38 Pain Relevance 0.19

General Comments

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