INT231769

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.75
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, HMOX1) signal transduction (TNF, HMOX1) transmembrane transport (HMOX1)
oxidoreductase activity (HMOX1) cell death (HMOX1) plasma membrane (TNF)
Anatomy Link Frequency
monocytes 6
TNF (Homo sapiens)
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 98.36 Very High Very High Very High
Inflammatory response 21 98.08 Very High Very High Very High
rheumatoid arthritis 30 97.84 Very High Very High Very High
ischemia 3 66.96 Quite High
cytokine 3 14.08 Low Low
Infliximab 6 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 6 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
INFLAMMATION 72 98.36 Very High Very High Very High
Rheumatoid Arthritis 30 97.84 Very High Very High Very High
Disease 237 96.24 Very High Very High Very High
Rheumatic Diseases 12 88.48 High High
Lung Injury 6 77.20 Quite High
Targeted Disruption 6 76.44 Quite High
Renal Disease 3 70.08 Quite High
Pulmonary Disease 3 69.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our previous study [26] we showed that TNF suppresses HO-1 expression levels in human peripheral monocytes, thereby accelerating inflammatory responses; this suggests that excessive TNF levels contribute to defective HO-1 expression.
TNF Negative_regulation (suppresses) of Gene_expression (expression) of HO-1 in monocytes associated with inflammatory response
1) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.20 Pain Relevance 0.12
Our recent study [26] showed that tumor necrosis factor (TNF) suppresses HO-1 expression in human monocytes, leading to augmentation of inflammatory responses, and that clinical efficacy of anti-TNF therapy is associated with restoration of HO-1 expression in circulating monocytes from patients with RA [26].
tumor necrosis factor Negative_regulation (suppresses) of Gene_expression (expression) of HO-1 in monocytes associated with necrosis, inflammatory response, cancer and rheumatoid arthritis
2) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.78 Pain Relevance 0.51
Our recent study [26] showed that tumor necrosis factor (TNF) suppresses HO-1 expression in human monocytes, leading to augmentation of inflammatory responses, and that clinical efficacy of anti-TNF therapy is associated with restoration of HO-1 expression in circulating monocytes from patients with RA [26].
TNF Negative_regulation (suppresses) of Gene_expression (expression) of HO-1 in monocytes associated with necrosis, inflammatory response, cancer and rheumatoid arthritis
3) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.76 Pain Relevance 0.51

General Comments

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