INT23177

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Context Info
Confidence 0.44
First Reported 1989
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 50
Total Number 53
Disease Relevance 16.99
Pain Relevance 10.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
monocytes 46
liver 4
blood 4
T cells 4
plasma 2
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 245 100.00 Very High Very High Very High
local anesthetic 37 99.98 Very High Very High Very High
anesthesia 447 97.88 Very High Very High Very High
Leflunomide 55 97.82 Very High Very High Very High
Paracetamol 35 97.80 Very High Very High Very High
Chronic pancreatitis 7 97.56 Very High Very High Very High
endometriosis 5 97.56 Very High Very High Very High
Inflammation 527 97.48 Very High Very High Very High
Dismenorea 4 96.84 Very High Very High Very High
antagonist 108 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 186 99.82 Very High Very High Very High
Injury 143 99.62 Very High Very High Very High
Suicidal Behaviour 3 99.52 Very High Very High Very High
Disease 100 99.08 Very High Very High Very High
Apoptosis 56 99.00 Very High Very High Very High
Acute Liver Failure 18 98.86 Very High Very High Very High
Cancer 268 97.68 Very High Very High Very High
Pancreatitis 112 97.56 Very High Very High Very High
Endometriosis 10 97.56 Very High Very High Very High
INFLAMMATION 628 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local anesthetics suppressed monocyte HLA-DR expression in a dose-dependent manner (P < 0.05) but had no effect on monocyte mCD14 expression.
Negative_regulation (suppressed) of Gene_expression (expression) of HLA-DR in monocyte associated with local anesthetic
1) Confidence 0.44 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.29 Pain Relevance 0.94
Our results show that local anesthetics suppress HLA-DR expression on the surface of human monocytes.
Negative_regulation (suppress) of Gene_expression (expression) of HLA-DR in monocytes associated with local anesthetic
2) Confidence 0.44 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.20 Pain Relevance 0.71
This study demonstrated that local anesthetics suppress HLA-DR expression on the surface of human monocytes.
Negative_regulation (suppress) of Gene_expression (expression) of HLA-DR in monocytes associated with local anesthetic
3) Confidence 0.44 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041592 Disease Relevance 0.28 Pain Relevance 0.88
Monocyte HLA-DR expression measured in whole blood was reduced in patients with major sepsis (n = 19) compared to normal subjects (n = 10).
Negative_regulation (reduced) of Gene_expression (expression) of HLA-DR in Monocyte associated with sepsis
4) Confidence 0.43 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2739399 Disease Relevance 0.17 Pain Relevance 0.11
DESIGN: Glandular cells in eutopic and ectopic endometria were analyzed immunohistochemically to localize the expression of HLA-DR antigen.
Spec (analyzed) Negative_regulation (localize) of Gene_expression (expression) of HLA-DR
5) Confidence 0.43 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.17 Pain Relevance 0
OBJECTIVE: To evaluate the expression of major histocompatibility complex class II antigen (human leukocyte antigen, HLA-DR) in glandular cells in eutopic and ectopic endometria in patients with endometriosis and adenomyosis.
Negative_regulation (evaluate) of Gene_expression (expression) of HLA-DR in leukocyte associated with endometriosis and dismenorea
6) Confidence 0.43 Published 1993 Journal Fertil. Steril. Section Abstract Doc Link 8224269 Disease Relevance 0.42 Pain Relevance 0.26
Regarding circulating monocytes, laparotomy seems to result in greater decreases in HLA-DR expression and monocyte-mediated cytotoxicity while at the same time activating monocytes to elaborate more TNF-alpha and superoxide anion than laparoscopic methods.
Negative_regulation (decreases) of Gene_expression (expression) of HLA-DR in monocytes
7) Confidence 0.35 Published 2001 Journal Surg. Oncol. Clin. N. Am. Section Abstract Doc Link 11685934 Disease Relevance 0.13 Pain Relevance 0.04
It can be seen that HLA-DR expression on CD14HIGH and CD14LOW monocytes at POD1 was decreased as shown by a leftward shift as compared to levels at T1.
Negative_regulation (decreased) of Gene_expression (expression) of HLA-DR in monocytes associated with anesthesia
8) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.11 Pain Relevance 0.56
In contrast, the expression of HLA-DR on CD14LOW cells did not change at T4, and was only reduced at POD1 (-40%) and POD2 (-51%) (Figure 3B).
Negative_regulation (reduced) of Gene_expression (expression) of HLA-DR
9) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.07 Pain Relevance 0.46
Decreased expression of HLA-DR was obtained for 69% of the plasma samples (9 out of 13 patients), with a 42 ± 9% decrease for CD14HIGH and a 11 ± 8% decrease for CD14LOW monocytes.
Negative_regulation (Decreased) of Gene_expression (expression) of HLA-DR in monocytes
10) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.07
In AAS, decreased HLA-DR expression already occurred during surgery for the CD14HIGH cells, earlier than that observed for the CD14LOW population and with a more pronounced effect.
Negative_regulation (decreased) of Gene_expression (expression) of HLA-DR
11) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.35 Pain Relevance 0.15
We then investigated whether the plasma of AAS patients could suppress the expression of HLA-DR on CD14HIGH and CD14LOW monocyte subpopulations of healthy donors.
Negative_regulation (suppress) of Gene_expression (expression) of HLA-DR in monocyte
12) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.14
Figure 3A shows that in AAS patients, HLA-DR expression on CD14HIGHcells was reduced after blood reperfusion (T4) (-49%) and continued to decrease by POD1 (-60%) and POD2 (-73%).
Negative_regulation (reduced) of Gene_expression (expression) of HLA-DR in blood
13) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.06 Pain Relevance 0.49
For CAS patients, the kinetics of the reduction of HLA-DR expression on CD14HIGH and CD14LOW cells were not different of that of AAS patients, but the reduction was significantly less severe.


Negative_regulation (reduction) of Gene_expression (expression) of HLA-DR
14) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.10 Pain Relevance 0.40
Regarding circulating monocytes, laparotomy seems to result in greater decreases in HLA-DR expression and monocyte-mediated cytotoxicity while at the same time activating monocytes to elaborate more TNF-alpha and superoxide anion than laparoscopic methods.
Negative_regulation (decreases) of Gene_expression (expression) of HLA-DR in monocytes
15) Confidence 0.26 Published 2001 Journal Surg. Oncol. Clin. N. Am. Section Abstract Doc Link 11685934 Disease Relevance 0.13 Pain Relevance 0.04
Conventional RT-PCR at 30 cycles revealed marked higher expression of HLA-DRA, LYZ, and CD14 transcripts in eEPCs, while CAV1, VE-cadherin, and vWF transcripts were only present in OECs (Figure 3A).
Negative_regulation (revealed) of Gene_expression (expression) of HLA-DRA
16) Confidence 0.24 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.07 Pain Relevance 0.04
In addition, for four AAS plasma, which led to a 37.3 ± 10.4% decrease of HLA-DR expression onto CD14HIGHmonocytes from healthy controls, the co-incubation with RU486, a glucocorticoid receptor antagonist, fully abolished the inhibitory effect of the active AAS plasma (data not shown).


Negative_regulation (decrease) of Gene_expression (expression) of HLA-DR in plasma associated with antagonist
17) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.05
Accordingly, we tested the capacity of IL-10 and glucocorticoids to down-regulate the expression of HLA-DR on either sub-population from healthy controls.
Negative_regulation (down) of Gene_expression (expression) of HLA-DR
18) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.03
In agreement with our in vivo observations, we showed that hydrocortisone was able to down-regulate HLA-DR expression on both monocyte subpopulations, whereas IL-10 only acted on CD14HIGH monocytes.
Negative_regulation (down) of Gene_expression (expression) of HLA-DR in monocyte
19) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.05 Pain Relevance 0.09
While it was already known that both mediators down-regulated the expression of HLA-DR on monocytes [21,44-46], their specific effects on monocyte subpopulation was not investigated.
Negative_regulation (down) of Gene_expression (expression) of HLA-DR in monocyte
20) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.03

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