INT231771

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (HMOX1, TNF) signal transduction (HMOX1, TNF) transmembrane transport (HMOX1)
cell death (HMOX1) oxidoreductase activity (HMOX1) plasma membrane (TNF)
Anatomy Link Frequency
monocytes 1
HMOX1 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Infliximab 2 87.20 High High
cytokine 7 37.84 Quite Low
Inflammation 18 37.48 Quite Low
rheumatoid arthritis 10 22.88 Low Low
Inflammatory response 7 16.60 Low Low
corticosteroid 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 57 97.60 Very High Very High Very High
Disease 98 80.88 Quite High
Necrosis 4 75.00 Quite High
Cancer 4 75.00 Quite High
Cerebral Malaria 33 68.76 Quite High
Vivax Malaria 11 66.72 Quite High
Falciparum Malaria 17 64.80 Quite High
Infection 7 43.76 Quite Low
Rheumatic Diseases 4 41.68 Quite Low
INFLAMMATION 26 37.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because our previous study demonstrated bidirectory interactions between HO-1 and TNF [26], we also examined effects of HO-1 upregulation on TLR levels in monocytes.
HO-1 Binding (interactions) of TNF in monocytes
1) Confidence 0.14 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.21 Pain Relevance 0.04
No significant association between HO-1 and TNF polymorphisms including the inducing effect of cadmium and malaria pathogenicity/severity was observed.


HO-1 Neg (No) Binding (association) of TNF associated with malaria
2) Confidence 0.13 Published 2010 Journal Malar J Section Abstract Doc Link PMC2949743 Disease Relevance 1.20 Pain Relevance 0

General Comments

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