INT23178

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 13.37
Pain Relevance 9.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skeletal muscle 2
nerves 2
T cells 2
smooth muscles 1
internal 1
H1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 50 100.00 Very High Very High Very High
halothane 8 100.00 Very High Very High Very High
analgesia 4 99.96 Very High Very High Very High
antinociception 3 99.96 Very High Very High Very High
lidocaine 22 99.88 Very High Very High Very High
metalloproteinase 1 99.72 Very High Very High Very High
qutenza 26 99.70 Very High Very High Very High
opiate 6 99.70 Very High Very High Very High
substance P 83 99.64 Very High Very High Very High
nociceptor 2 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 320 99.92 Very High Very High Very High
Hypersensitivity 22 99.90 Very High Very High Very High
Influenza Virus Infection 585 99.84 Very High Very High Very High
Pox Virus Infection 115 99.84 Very High Very High Very High
Stress 88 99.34 Very High Very High Very High
Pruritus 7 99.16 Very High Very High Very High
Cytomegalovirus Infection 104 99.12 Very High Very High Very High
Targeted Disruption 22 99.06 Very High Very High Very High
Immunization 121 99.02 Very High Very High Very High
Pain 16 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The H1 blockers, including an ethylenediamine (pyrilamine), an ethanolamine (diphenhydramine), a phenothiazine (methdilazine), a piperazine (cyclizine) and an alkylamine (chlorpheniramine), all produced antinociception when given alone to mice and also caused potentiation when combined with morphine.
Gene_expression (produced) of H1 associated with antinociception and morphine
1) Confidence 0.68 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 2858829 Disease Relevance 0 Pain Relevance 0.44
The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis.
Gene_expression (overexpression) of histocompatibility in skeletal muscle associated with stress and myositis
2) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888201 Disease Relevance 0.72 Pain Relevance 0.11
Using transgenic mice, Nagaraju and colleagues showed that the overexpression of class I major histocompatibility complex antigen (MHC-I) in skeletal muscle fibers was responsible for the chronic activation of the endoplasmic reticulum (ER) stress-response and the development of myositis [4].
Gene_expression (overexpression) of histocompatibility in skeletal muscle associated with stress, targeted disruption and myositis
3) Confidence 0.58 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 1.06 Pain Relevance 0.08
Opiate and histamine H1 receptors are present on some substance P-containing dorsal root ganglion cells.
Gene_expression (present) of H1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, opiate and substance p
4) Confidence 0.58 Published 1985 Journal Neurosci. Lett. Section Title Doc Link 2581181 Disease Relevance 0.25 Pain Relevance 0.90
To address this question, we examined the effects of neonatal capsaicin treatment on allergic reactions and H1 histamine receptor-expressing sensory neurones in mice.
Gene_expression (expressing) of H1 associated with qutenza and hypersensitivity
5) Confidence 0.55 Published 2008 Journal Acta Derm. Venereol. Section Abstract Doc Link 18779880 Disease Relevance 0.75 Pain Relevance 0.39
Different roles of capsaicin-sensitive and H1 histamine receptor-expressing sensory neurones in itch of mosquito allergy in mice.
Gene_expression (expressing) of H1 associated with qutenza, hypersensitivity and pruritus
6) Confidence 0.55 Published 2008 Journal Acta Derm. Venereol. Section Title Doc Link 18779880 Disease Relevance 0.78 Pain Relevance 0.55
The anticonvulsive effect of morphine (1 mg/kg, i.p.) was antagonized by histamine H1-receptor antagonists, dimethindene (0.1 mg/kg, i.p.) promethazine (0.4 mg/kg, i.p.) and pheniramine (30 mg/kg, i.p.), and naloxone (10 mg/kg, i.p.), but not by the H2-receptor antagonist ranitidine (10-50 micrograms, i.c.v.).
Gene_expression (antagonists) of H1 associated with antagonist, narcan and morphine
7) Confidence 0.54 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8835636 Disease Relevance 0.26 Pain Relevance 0.78
The results demonstrate the presence of both H1 and H2 postsynaptic receptors which are involved in the direct myogenic action of HA on guinea pig gastric fundus smooth muscles.
Gene_expression (presence) of H1 in smooth muscles
8) Confidence 0.50 Published 1996 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8721254 Disease Relevance 0 Pain Relevance 0.14
Although no comparative data with other H1 antagonists exist, fexofenadine 180 mg once daily was effective in reducing the symptoms of chronic idiopathic urticaria for up to 6 weeks.
Gene_expression (exist) of H1 associated with urticaria and antagonist
9) Confidence 0.43 Published 2000 Journal Drugs Section Abstract Doc Link 10730552 Disease Relevance 0.62 Pain Relevance 0.18
Expression of the H1 or N1 proteins by recombinant vaccinia viruses was detected by Western blotting.
Gene_expression (Expression) of H1 associated with pox virus infection
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.59 Pain Relevance 0
The family-based haplotype association analysis identified the most frequent allele H1 as overtransmitted to affected children with a high significance level (Table 4; P?
Gene_expression (overtransmitted) of H1
11) Confidence 0.26 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.07 Pain Relevance 0.04
This procedure was repeated until the dose volume was 4.0 µl. 2 µg of the vaccine antigen H1, produced as previously described [19], was added before up-concentration.
Gene_expression (produced) of H1
12) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993957 Disease Relevance 0.08 Pain Relevance 0
When using the H1 CA/07 peptide pool for stimulation of the splenocytes, 1.3–1.4% of the CD4 T-cells produced IFN-?
Gene_expression (using) of H1 in T-cells
13) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.32 Pain Relevance 0.04
When using the N1 CA/07 peptide pool for stimulation of the cells, 3–4% of total CD8-T cells were NA-specific, whereas the H1 peptide pool, used as a negative control in this case, did not induce any IFN-?
Gene_expression (pool) of H1 in T cells
14) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.28 Pain Relevance 0
The H1 and N1 genes were synthetic genes optimized for expression in vaccinia virus, lacking internal transcription stop signals [21].
Gene_expression (expression) of H1 in internal associated with pox virus infection
15) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.80 Pain Relevance 0
To detect the H1 protein, a sheep antiserum against the A/California/7/2009 hemagglutinin (NIBSC 09/152) was used.
Gene_expression (detect) of H1
16) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.36 Pain Relevance 0
To demonstrate the utility of pHUSH as a technology by which to interrogate the role of a target gene within relevant tumor models in vivo, we constructed a retroviral pHUSH vector with a luciferase-directed shRNA using the H1-TetO2 promoter.
Gene_expression (using) of H1 associated with cancer
17) Confidence 0.22 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.10 Pain Relevance 0.03
A simple strategy we have found for maximizing the level of silencing when using the H1-shRNA pHUSH vectors is to escalate the selection pressure downstream of the TetR (additional file 4)
Gene_expression (using) of H1
18) Confidence 0.22 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.36 Pain Relevance 0
A modified H1 promoter containing a single TetR operon with a Melk-targeting shRNA cassette was inserted upstream to the human-?
Gene_expression (promoter) of H1
19) Confidence 0.22 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.32 Pain Relevance 0
In summary, the presence of multiple TetR operons within the H1 promoter does not significantly effect maximal shRNA expression while promoting Dox regulated gene silencing even under limiting TetR expression levels.


Gene_expression (expression) of H1
20) Confidence 0.22 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.13 Pain Relevance 0

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