INT231820

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 5.43
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Irf8) DNA binding (Irf8)
Anatomy Link Frequency
germinal center B cells 2
marginal zone 1
developmental stage 1
lung 1
Irf8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 42 86.40 High High
Inflammatory response 1 82.92 Quite High
Inflammatory mediators 1 80.72 Quite High
rheumatoid arthritis 4 45.12 Quite Low
agonist 4 32.56 Quite Low
chemokine 20 16.80 Low Low
corticosteroid 13 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 488 99.84 Very High Very High Very High
Mantle-cell Lymphoma 132 97.24 Very High Very High Very High
Cancer 165 96.68 Very High Very High Very High
Diffuse Large B-cell Lymphoma 224 89.24 High High
Lung Injury 40 89.20 High High
Follicular Lymphoma 88 88.36 High High
INFLAMMATION 35 86.40 High High
Sprains And Strains 2 84.40 Quite High
Pressure And Volume Under Development 1 79.12 Quite High
Necrosis 1 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B, ICSBP, and PU.1) detected in the lung tissue are not upregulated by mechanical ventilation [49,50].
Gene_expression (detected) of ICSBP in lung
1) Confidence 0.19 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 1.26 Pain Relevance 0.19
Germinal center B cells contained the highest levels of IRF8 with lower levels seen in mantle and marginal zone B cells and none in plasma cells.
Gene_expression (levels) of IRF8 in Germinal center B cells
2) Confidence 0.17 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.03 Pain Relevance 0
Similarly, IRF8 was most strongly expressed in lymphomas of germinal center origin with lower levels present in MCL, CLL, and marginal zone lymphomas, and no expression observed in plasmacytic/plasmablastic neoplasms.
Gene_expression (expressed) of IRF8 in marginal zone associated with mantle-cell lymphoma, lymphatic system cancer and cancer
3) Confidence 0.17 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.05 Pain Relevance 0
Although IRF8 was detectable in most reactive B cells, its expression levels differed with developmental stage.
Gene_expression (detectable) of IRF8 in developmental stage
4) Confidence 0.17 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.05 Pain Relevance 0
IRF8 was coexpressed with PAX-5, Pu.1, and BCL 6 and similar to BCL6, was absent from the small population of IRF4-positive germinal center B cells thought to be committed to postgerminal center developmental programs.
Neg (absent) Gene_expression (coexpressed) of IRF8 in germinal center B cells
5) Confidence 0.17 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.04 Pain Relevance 0

General Comments

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