INT231821

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Pcdh8) plasma membrane (Pcdh8)
Pcdh8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 76 79.76 Quite High
ketamine 2 54.56 Quite High
cytokine 8 40.56 Quite Low
agonist 8 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Injury 80 99.52 Very High Very High Very High
Pneumonia 18 79.76 Quite High
INFLAMMATION 62 79.52 Quite High
Stress 18 75.12 Quite High
Shock 2 33.80 Quite Low
Atherosclerosis 2 22.40 Low Low
Injury 2 12.08 Low Low
Adult Respiratory Distress Syndrome 42 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we used rodent models of VILI and pulmonary ECs exposed to physiologic and pathologic levels of cyclic stretch (CS) and thrombin stimulation to test the hypotheses that vascular leak caused by mechanical ventilation at HTVs involves the Rho pathway of endothelial barrier dysfunction and that OxPAPC may attenuate Rho activation induced by VILI-associated pathologic mechanochemical stimulation via Rac-dependent mechanisms.
Positive_regulation (activation) of OxPAPC associated with lung injury
1) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.27 Pain Relevance 0.03
In vitro, the effects of OxPAPC on endothelial barrier dysfunction and GTPase activation were assessed in cells exposed to thrombin and pathologic (18%) cyclic stretch.


Positive_regulation (activation) of OxPAPC
2) Confidence 0.01 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2374596 Disease Relevance 0.58 Pain Relevance 0.18

General Comments

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