INT231823

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.34
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cel) extracellular space (Cel) extracellular region (Cel)
Golgi apparatus (Cel) protein complex (Cel) cytoplasm (Cel)
Anatomy Link Frequency
lung 4
Cel (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 99 99.54 Very High Very High Very High
Inflammatory mediators 9 92.12 High High
cva 1 46.88 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 100 99.54 Very High Very High Very High
Lung Injury 40 98.16 Very High Very High Very High
Weight Loss 8 97.52 Very High Very High Very High
Stress 9 93.56 High High
Pneumonia 15 93.24 High High
Adult Respiratory Distress Syndrome 21 88.84 High High
Parainfluenza Virus Infection 5 83.36 Quite High
Respiratory Syncytial Virus 41 78.48 Quite High
Asthma 7 75.64 Quite High
Viral Infection 8 73.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the peak of acute inflammation (day 8), azithromycin decreased total leukocyte accumulation in the lung tissue and BAL, with the largest fold-reduction in BAL neutrophils.
Negative_regulation (decreased) of Positive_regulation (accumulation) of BAL in lung associated with inflammation
1) Confidence 0.17 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2906448 Disease Relevance 1.64 Pain Relevance 0.49
Pharmacologic inhibition of Rho-associated kinase by Y-27632 markedly attenuated HTV-induced increases in lung BAL cell count and protein content in our murine VILI model (Figure 5a,b), suggesting the involvement of Rho signaling in the lung dysfunction caused by mechanical stress.
Negative_regulation (inhibition) of Positive_regulation (increases) of BAL in lung associated with stress and lung injury
2) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.69 Pain Relevance 0.07

General Comments

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