INT231842

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.59
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pcdh8, Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
lung 2
vascular endothelium 1
Pcdh8 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 152 97.22 Very High Very High Very High
cytokine 16 77.08 Quite High
agonist 16 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Injury 160 99.72 Very High Very High Very High
Pneumonia 36 97.22 Very High Very High Very High
INFLAMMATION 124 96.14 Very High Very High Very High
Adult Respiratory Distress Syndrome 84 85.28 High High
Syndrome 16 76.64 Quite High
Sprains And Strains 8 71.04 Quite High
Disease 4 66.36 Quite High
Stress 36 33.92 Quite Low
Thrombosis 4 5.00 Very Low Very Low Very Low
Exsanguination 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to HPAEC cultures, direct activation of Rac by OxPAPC and OxPAPC-mediated attenuation of thrombin-induced Rho activity has also been observed in the lung microvascular EC cultures (data not shown).
OxPAPC Positive_regulation (activation) of Rac in lung
1) Confidence 0.00 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.07 Pain Relevance 0
In contrast to the direct effects of OxPAPC on inhibition of the TLR-4-mediated inflammatory cascade in the model of LPS-induced lung inflammation and vascular dysfunction, we attribute the protective effects of OxPAPC on the lung vascular endothelium in the aseptic VILI model to the OxPAPC-induced activation of Rac signaling and reduction of Rho-induced endothelial hyperpermeability.
OxPAPC-induced Positive_regulation (activation) of Rac in vascular endothelium associated with lung injury, inflammation and pneumonia
2) Confidence 0.00 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 1.17 Pain Relevance 0.29
These effects were dramatically attenuated by OxPAPC and were associated with OxPAPC-induced activation of Rac.


OxPAPC-induced Positive_regulation (activation) of Rac
3) Confidence 0.00 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2374596 Disease Relevance 0.28 Pain Relevance 0.11
Similar to HPAEC cultures, direct activation of Rac by OxPAPC and OxPAPC-mediated attenuation of thrombin-induced Rho activity has also been observed in the lung microvascular EC cultures (data not shown).
OxPAPC Positive_regulation (activation) of Rac in lung
4) Confidence 0.00 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.07 Pain Relevance 0

General Comments

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